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T-Cell Surface Glycoprotein CD5, human

Known as: Lymphocyte Antigen CD5, CD5, T-Cell Surface Glycoprotein CD5 
T-cell surface glycoprotein CD5 (495 aa, ~54 kDa) is encoded by the human CD5 gene. This protein may be involved in regulating the proliferation of T… 
National Institutes of Health

Related topics

Related topics

10 relations
Antigens, CD5CD5 Ag:PrThr:Pt:Tiss:Ord:Immune stainCD5 geneDendritic Cell Pathway

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
CD5 and B lymphocyte responses: multifaceted effects through multitudes of pathways and channels
CD5 + B lymphocytes, also known as B1 cells, play key roles in the immune system. This subset of B cells is a focus of renewed… 
Review
2019
Review
2019
The multiple faces of CD5
Since its discovery, over 30 years ago, CD5 has been used as a marker to identify T cells, B1‐a cells, and B cell chronic… 
Review
2012
Review
2012
Basic Science for the Clinician 54: CD5
AbstractThe full story of what surface markers mean about the cells on which they reside twists and turns as the days go by, with… 
Highly Cited
2006
Highly Cited
2006
CD5-CK2 Binding/Activation-Deficient Mice Are Resistant to Experimental Autoimmune Encephalomyelitis: Protection Is Associated with Diminished Populations of IL-17-Expressing T Cells in the Central…
Regulating the differentiation and persistence of encephalitogenic T cells is critical for the development of experimental… 
Highly Cited
2003
Highly Cited
2003
B cells in the aged: CD27, CD5, and CD40 expression
Highly Cited
2003
Highly Cited
2003
CD5 Inhibits Signaling at the Immunological Synapse Without Impairing Its Formation 1
Physiologically, Ag detection by T cells occurs at the immunological synapse (IS) formed at the interface with an APC. CD5 is… 
1999
1999
Identification of a natural soluble form of human CD5.
CD5 is a 67 kDa type I glycoprotein which belongs to the Scavenger Receptor Cysteine-Rich (SRCR) family of receptors. This family… 
Highly Cited
1999
Highly Cited
1999
CD5 Negatively Regulates the T-Cell Antigen Receptor Signal Transduction Pathway: Involvement of SH2-Containing Phosphotyrosine Phosphatase SHP-1
ABSTRACT The negative regulation of T- or B-cell antigen receptor signaling by CD5 was proposed based on studies of thymocytes… 
Highly Cited
1996
Highly Cited
1996
Identification of a novel inducible cell-surface ligand of CD5 on activated lymphocytes
CD5 is a 67-kD glycoprotein that is expressed on most T lymphocytes and on a subset of mature B cells. Although its physiologic… 
Highly Cited
1992
Highly Cited
1992
CD5 is phosphorylated on tyrosine after stimulation of the T-cell antigen receptor complex.
When T cells are activated by the T-cell antigen receptor, a number of cellular proteins are phosphorylated on tyrosine. We… 
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