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Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 −1082 promoter SNP and its interaction with TNF-α −308 promoter SNP
Ageing is associated with chronic, low grade inflammatory activity leading to long term tissue damage, and systemic chronic inflammation has been found to be related to mortality risk from all causesExpand
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A double-negative (IgD−CD27−) B cell population is increased in the peripheral blood of elderly people
The T cell branch of the immune system has been extensively studied in the elderly and it is known that the elderly have impaired immune function, mainly due to the chronic antigenic load thatExpand
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Innate immunity and inflammation in ageing: a key for understanding age-related diseases
The process of maintaining life for the individual is a constant struggle to preserve his/her integrity. This can come at a price when immunity is involved, namely systemic inflammation. InflammationExpand
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Gender-specific association between −1082 IL-10 promoter polymorphism and longevity
Ageing is characterized by a pro-inflammatory status, which could contribute to the onset of major age-related diseases. Thus, genetic variations in pro- or anti-inflammatory cytokines mightExpand
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Understanding ageing: Biomedical and bioengineering approaches, the immunologic view
During the past century, humans have gained more years of average life expectancy than in the last 10,000 years; we are now living in a rapidly ageing world. The sharp rise in life expectancy,Expand
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Inflammation, cytokines, immune response, apolipoprotein E, cholesterol, and oxidative stress in Alzheimer disease: therapeutic implications.
Alzheimer disease (AD) is a heterogeneous and progressive neurodegenerative disease, which in Western society mainly accounts for senile dementia. Today many countries have rising aging populationsExpand
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Immune profiling of Alzheimer patients
Alzheimer's disease (AD) is characterized by extracellular senile plaques in the brain, containing amyloid-β peptide (Aβ). We identify immunological differences between AD patients and age-matchedExpand
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Association between C1019T polymorphism of connexin37 and acute myocardial infarction: a study in patients from Sicily.
During atherogenesis, a critical role is played by intercellular communication via gap junctions, cell membrane channels linking the cytoplasmic compartments of adjacent cells. The component proteinExpand
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Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease
Proinflammatory cytokines and acute-phase proteins play an important role in Alzheimer's disease (AD) neurodegeneration, and common polymorphisms of genes controlling their high production have beenExpand
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Association between longevity and cytokine gene polymorphisms. A study in Sardinian centenarians
  • G. Pes, D. Lio, +10 authors C. Caruso
  • Biology, Medicine
  • Aging clinical and experimental research
  • 1 June 2004
Background and aims: Human longevity seems to be directly correlated with optimal functioning of the immune system, suggesting that some genetic determinants of longevity reside in thoseExpand
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