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T-Cell Surface Glycoprotein, human

Known as: Cortical Thymocyte Antigen CD1A, T-Cell Surface Antigen T6/Leu-6, Antigen CD1a 
T-cell surface glycoprotein CD1a (327 aa, ~37 kDa) is encoded by the human CD1A gene. This protein is involved in the mediation of lipid and… 
National Institutes of Health

Related topics

Related topics

12 relations
Antigen PresentationCD1A geneImmune System ProcessesImmunoproteins

Broader (2)

Antigens, CD1CD1a antigen

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Early Recycling Compartment Trafficking of CD1a Is Essential for Its Intersection and Presentation of Lipid Antigens
A major step in understanding differences in the nature of Ag presentation was the realization that MHC class I samples peptides… 
2008
2008
Regulation of CD1a Surface Expression and Antigen Presentation by Invariant Chain and Lipid Rafts1
In immature dendritic cells (DCs), CD1a is almost exclusively expressed at the cell surface and its membrane organization is… 
Highly Cited
2004
Highly Cited
2004
Endogenously expressed HIV-1 nef down-regulates antigen-presenting molecules, not only class I MHC but also CD1a, in immature dendritic cells.
Highly Cited
2002
Highly Cited
2002
Dendritic cell density and activation status in human breast cancer – CD1a, CMRF-44, CMRF-56 and CD-83 expression
Low CD1a-positive putative dendritic cell numbers in human breast cancer has recently been described and may explain the apparent… 
Highly Cited
2001
Highly Cited
2001
CD1a molecules traffic through the early recycling endosomal pathway in human Langerhans cells.
In this work, we studied the localization and traffic of CD1a molecules in human epidermal Langerhans cells and the ability of… 
1999
1999
Characterization of human skin-derived CD1a-positive lymph cells
Abstract The phenotype and function of CD1a + lymph cells is of considerable interest. By means of microsurgical lymph… 
1998
1998
Topical tretinoin replenishes CD1a‐positive epidermal Langerhans cells in chronically photodamaged human skin
Excessive exposure to sunlight results in drastic degradative changes in the constitutive cells of the epidermis. Among these is… 
Highly Cited
1993
Highly Cited
1993
Epidermal Langerhans cells are resistant to the permeabilizing effects of extracellular ATP: in vitro evidence supporting a protective role of membrane ATPase.
Extracellular adenosine 5'-triphosphate (ATPo) can induce pore formation in cell membranes, leading to cell permeabilization and… 
Highly Cited
1989
Highly Cited
1989
Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.
The CD1 gene family encodes at least three proteins: CD1a, CD1b, and CD1c, which are coexpressed on cortical thymocytes and a… 
1989
1989
Reappearance of CD1a antigenic sites after endocytosis on human Langerhans cells evidenced by immunogoldrelabeling.
We show evidence of the reappearance of CD1a antigenic sites on the surface of human isolated Langerhans cells after… 
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