T-Cell Receptors alpha-Chain

Known as: T-Cell Receptor Alpha Chain, TRA, T Cell Receptors alpha Chain 
One component of the alpha-beta T-cell receptor. Encoded by a locus on chromosome 14. Somatic recombination results in formation of the active gene.
National Institutes of Health

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T-Cell ActivationTRA genealpha-beta T-Cell Receptor

Papers overview

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Highly Cited
2011
Highly Cited
2011
Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation.
Interleukin-23 (IL-23) and CD4(+) T helper 17 (Th17) cells are thought to be critical in psoriasis pathogenesis. Here, we report… (More)
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Highly Cited
2011
Highly Cited
2011
Paired analysis of TCRα and TCRβ chains at the single-cell level in mice.
Characterizing the TCRα and TCRβ chains expressed by T cells responding to a given pathogen or underlying autoimmunity helps in… (More)
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Highly Cited
2011
Highly Cited
2011
A role for cohesin in T cell receptor rearrangement and thymocyte differentiation
Cohesin enables post-replicative DNA repair and chromosome segregation by holding sister chromatids together from the time of DNA… (More)
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Review
2009
Review
2009
Mechanics of T cell receptor gene rearrangement.
The four T cell receptor genes (Tcra, Tcrb, Tcrg, Tcrd) are assembled by V(D)J recombination according to distinct programs… (More)
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2006
2006
Regulation of T cell receptor-alpha gene recombination by transcription.
Despite the longstanding correlation between transcription and variable-(diversity)-joining (V(D)J) recombination, it is unknown… (More)
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Highly Cited
2005
Highly Cited
2005
New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling
To gain more insight into initiation and regulation of T cell receptor (TCR) gene rearrangement during human T cell development… (More)
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Highly Cited
2005
Highly Cited
2005
The immunoglobulin heavy-chain locus in zebrafish: identification and expression of a previously unknown isotype, immunoglobulin Z
The only immunoglobulin heavy-chain classes known so far in teleosts have been μ and δ. We identify here a previously unknown… (More)
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Highly Cited
1999
Highly Cited
1999
Ig heavy chain gene rearrangements in T-cell acute lymphoblastic leukemia exhibit predominant DH6-19 and DH7-27 gene usage, can result in complete V-D-J rearrangements, and are rare in T-cell…
Rearranged IGH genes were detected by Southern blotting in 22% of 118 cases of T-cell acute lymphoblastic leukemia (ALL) and… (More)
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Review
1995
Review
1995
Human T-cell receptor variable gene segment families
Multiple DNA and protein sequence alignments have been constructed for the human T-cell receptor α/δ, β, and γ (TCRA/D, B, and G… (More)
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Review
1995
Review
1995
Mouse T-cell receptor variable gene segment families
All mouse T-cell receptor α/δ, β, and γ variable (Tcra/d, b-, and g-V) gene segments were aligned to compare the sequences with… (More)
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