T 98475

Known as: T-98475

National Institutes of Health

Papers overview

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Highly Cited

2003

Highly Cited

2003

Discovery of a thieno[2,3-d]pyrimidine-2,4-dione bearing a p-methoxyureidophenyl moiety at the 6-position: a highly potent and orally bioavailable non-peptide antagonist for the human luteinizing…

We have previously disclosed the first potent and orally effective non-peptide antagonist for the human luteinizing hormone…

2000

2000

Consensus bioactive conformation of cyclic GnRH antagonists defined by NMR and molecular modeling.

Little is known of the conformation of peptide hormones as they interact with their receptors for a number of reasons: peptide…