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Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
This work characterized another mammalian member of the CRF family and localized its urotensin-like immunoreactivity to, and cloned related complementary DNAs from, a discrete rat midbrain region, and deduced a peptide that is related to u Rotensin and CRF, which is named urocortin, which could be an endogenous ligand for type-2 CRF receptors. Expand
Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone
A peptide has been isolated from ovine hypothalamus which, at 1 x 10-9M, inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats. ItsExpand
NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor.
It is proposed that the ECD1 captures the C-terminal segment of the ligand, whose N terminus then penetrates into the transmembrane region of the receptor to initiate signaling. Expand
Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules
It is found that peptide and protein hormones in secretory granules of the endocrine system are stored in an amyloid-like cross–β-sheet–rich conformation, which means functional amyloids in the pituitary and other organs can contribute to normal cell and tissue physiology. Expand
Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
The approach described here permits the application of recombinant DNA technology to analyses of complex neurobiological systems in the absence of prior structural or biological information. Expand
Appetite-Suppressing Effects of Urocortin, a CRF-Related Neuropeptide
Urocortin may be an endogenous CRF-like factor in the brain responsible for the effects of stress on appetite, and doses as low as 10 nanograms injected intracerebroventricularly were effective in decreasing food intake in food-deprived and free-feeding rats. Expand
Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour
A synthetic replicate of this peptide, termed human pancreatic tumour GRF [hpGRF(1–40)]-OH, co-elutes on HPLC with the native peptide and is highly potent in stimulating GH secretion in vitro and in vivo. Expand
Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid
The purification of an FSH releasing protein (FRP) and its characterization by SDS-polyacrylamide gel electrophoresis under non-reducing and reducing conditions and by partial sequence analysis indicate that porcine gonadal FRP is a homodimer consisting of two inhibin βA-chains linked by disulphide bonds. Expand