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T 1032

Known as: T-1032, methyl 2-(4-aminophenyl)-1,2-dihydro-1-oxo-7-(2-pyridinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-3-isoquinolinecarboxylate 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

IsoquinolinesPyridines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Nitric oxide activity through guanylate cyclase and phosphodiesterase modulation is impaired in fetal lambs with congenital diaphragmatic hernia.
2007
2007
Blockade of phosphodiesterase Type 5 enhances rat neurohypophysial excitability and electrically evoked oxytocin release
Phosphodiesterase type 5 (PDE5) acts specifically on cyclic guanosine monophosphate (cGMP) and terminates cGMP‐mediated… 
2004
2004
Long-Term Treatment with a Phosphodiesterase Type 5 Inhibitor Improves Pulmonary Hypertension Secondary to Heart Failure through Enhancing the Natriuretic Peptides-cGMP Pathway
In advanced heart failure (HF), the compensatory pulmonary vasodilation is attenuated due to the relative insufficiency of cGMP… 
2003
2003
T‐1032, a cyclic GMP phosphodiesterase‐5 inhibitor, acutely blocks physiologic insulin‐mediated muscle haemodynamic effects and glucose uptake in vivo
Cyclic GMP phosphodiesterase‐5 inhibitors have been shown to alter blood flow in specific tissues by potentiating local NO… 
Highly Cited
2002
Highly Cited
2002
Chronic hypoxia attenuates cGMP-dependent pulmonary vasodilation.
Chronic hypoxia (CH) augments endothelium-derived nitric oxide (NO)-dependent pulmonary vasodilation; however, responses to… 
2002
2002
Acute and chronic effects of T-1032, a novel selective phosphodiesterase type 5 inhibitor, on monocrotaline-induced pulmonary hypertension in rats.
We examined the hemodynamic property of T-1032 (methyl 2-(4-aminophenyl)-1,2-dihydro-1-oxo-7-(2-pyridylmethoxy)-4-(3,4,5… 
2002
2002
T-1032, a novel phosphodiesterase type 5 inhibitor, increases the survival of cardiomyopathic hamsters.
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