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The Sigma Receptor as a Ligand-Regulated Auxiliary Potassium Channel Subunit
The sigma receptor is a novel protein that mediates the modulation of ion channels by psychotropic drugs through a unique transduction mechanism depending neither on G proteins nor proteinExpand
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cGMP and S-nitrosylation: two routes for modulation of neuronal excitability by NO
The nitric oxide (NO)-cGMP signaling cascade has been implicated in synaptic plasticity and, more broadly, in the control of many forms of electrical activity. This raises the issue of how theseExpand
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The Hallucinogen N,N-Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator
The sigma-1 receptor is widely distributed in the central nervous system and periphery. Originally mischaracterized as an opioid receptor, the sigma-1 receptor binds a vast number of syntheticExpand
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Capacitance steps and fusion pores of small and large-dense-core vesicles in nerve terminals
The vesicles that package neurotransmitters fall into two distinct classes, large dense-core vesicles (LDCVs) and small synaptic vesicles, the coexistence of which is widespread in nerve terminals.Expand
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Synaptotagmin Modulation of Fusion Pore Kinetics in Regulated Exocytosis of Dense-Core Vesicles
In the exocytosis of neurotransmitter, fusion pore opening represents the first instant of fluid contact between the vesicle lumen and extracellular space. The existence of the fusion pore has beenExpand
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Different domains of synaptotagmin control the choice between kiss-and-run and full fusion
Exocytosis—the release of the contents of a vesicle—proceeds by two mechanisms. Full fusion occurs when the vesicle and plasma membranes merge. Alternatively, in what is termed kiss-and-run, vesiclesExpand
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Action potential broadening and frequency-dependent facilitation of calcium signals in pituitary nerve terminals.
Hormone release from nerve terminals in the neurohypophysis is a sensitive function of action potential frequency. We have investigated the cellular mechanisms responsible for thisExpand
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Transmembrane Segments of Syntaxin Line the Fusion Pore of Ca2+-Triggered Exocytosis
The fusion pore of regulated exocytosis is a channel that connects and spans the vesicle and plasma membranes. The molecular composition of this important intermediate structure of exocytosis isExpand
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Calcium Dynamics, Buffering, and Buffer Saturation in the Boutons of Dentate Granule-Cell Axons in the Hilus
The axons of dentate gyrus granule cells form synapses in the hilus. Ca2+ signaling was investigated in the boutons of these axons using confocal fluorescence imaging. Boutons were loaded withExpand
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Successive openings of the same acetylcholine receptor channel are correlated in open time.
Previous analysis of single-channel current records has shown that both the opening and closing transitions of chemically activated ion channels are operated by fast and slow kinetic processes. TheExpand
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