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T 0509

Known as: T-0509 
National Institutes of Health

Papers overview

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1999
1999
Binding pockets of the beta(1)- and beta(2)-adrenergic receptors for subtype-selective agonists.
We examined the subtype-selective binding site of the beta-adrenergic receptors (betaARs). The beta(1)/beta(2)-chimeric receptors… 
1995
1995
Desensitization and selective down-regulation of rat cardiac beta 1-adrenoceptors by prolonged in vivo infusion of T-0509, a beta 1-adrenoceptor full agonist.
We studied the effects of prolonged infusion of a selective beta 1-adrenoceptor (beta 1AR) full agonist, T-0509 [(-)-(R)-1-(3,4… 
1995
1995
Subcellular Fractions of Cyclic AMP and Cyclic AMP‐Dependent Protein Kinase and the Positive Inotropic Effects of Selective β1 -and β2-Adrenoceptor Agonists in Guinea Pig Hearts
We studied the effects of a full beta 1-adrenoceptor agonist (T-0509), a beta 2-adrenoceptor agonist (procaterol) and a… 
1994
1994
Sensitive determination of (-)-isoproterenol and (-)-(R)-1-(3,4- dihydroxyphenyl)-2-[(3,4-dimethoxyphenethyl)amino] ethanol (T-0509), a cardiotonic agent, in rat plasma utilizing a fully automated…
(-)-Isoproterenol (ISO), used as bronchodilator, and (-)-(R)-1-(3,4-dihydroxyphenyl)-2-[(3,4-dimethoxyphenethyl)amino]ethanol (T… 
1994
1994
Functional β-adrenoceptors in the left atrium of normotensive and hypertensive rats
1. The aim of the study was to characterize the functional beta 1-and beta 2-adrenoceptors of the rat left atrium and to… 
1994
1994
Binding of a catechol derivative of denopamine (T-0509) and N-tert-butylnoradrenaline (Colterol) to beta 1- and beta 2-adrenoceptors.
The affinities for beta-adrenoceptors, the subtype-selectivity and the agonistic effectiveness of T-0509 (a catechol derivative… 
1994
1994
Hemodynamic and coronary vasodilative properties of a selective and full beta 1-adrenoceptor agonist, T-0509, in comparison with isoproterenol in anesthesized dogs.
Recently, the beta 1-adrenoceptor was shown to mediate direct coronary vasodilation independent of metabolic demand in canine… 
1993
1993
ICI 147,798 Causes Insurmountable Antagonism Against T‐0509, a Selective β1-Adrenoceptor Agonist, but Surmountable Antagonism Against Isoproterenol
In canine right ventricular muscle, the influence of ICI 147,798, a slowly dissociable β1-adrenoceptor antagonist, on the… 
1992
1992
Selective and full β1‐adrenoceptor agonist action of a catechol derivative of denopamine (T‐0509) in the guinea‐pig cardiac muscle and trachea: comparison with denopamine, xamoterol and isoprenaline
1 The pharmacological actions of T‐0509, a 3‐hydroxy derivative of denopamine, were studied in various guinea‐pig tissues; these… 
1990
1990
Selective β1-Receptor Full Agonists, T‐0509 and T‐1583, Increase the Force Monophasically and Cyclic AMP Biphasically in Canine Ventricular Muscle
Summary In canine right ventricular muscle, we investigated the mechanism of action of the positive inotropic effects of T-0509… 
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