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Synphilin-1

Known as: Alpha-Synuclein-Interacting Protein, Sph1 
Synphilin-1 (919 aa, ~100 kDa) is encoded by the human SNCAIP gene. This protein is involved in the modulation of ubiquitin ligase activity.
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
PTEN-induced putative kinase 1 (PINK1) and parkin are mutated in familial forms of Parkinson's disease and are important in… Expand
Highly Cited
2009
Highly Cited
2009
Mutations in PARKIN, pten-induced putative kinase 1 (PINK1), and DJ-1 are individually linked to autosomal recessive early-onset… Expand
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Highly Cited
2005
Highly Cited
2005
It is widely accepted that the familial Parkinson's disease (PD)-linked gene product, parkin, functions as a ubiquitin ligase… Expand
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Highly Cited
2004
Highly Cited
2004
Lewy bodies (LBs), which are the hallmark pathologic features of Parkinson's disease and of dementia with LBs, have several… Expand
Highly Cited
2003
Highly Cited
2003
Loss-of-function mutations in parkin are the major cause of early-onset familial Parkinson's disease. To investigate the… Expand
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Highly Cited
2003
Highly Cited
2003
Parkinson's disease is a common neurodegenerative disorder characterized by loss of dopaminergic neurons and appearance of Lewy… Expand
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Highly Cited
2001
Highly Cited
2001
Parkinson disease is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons and the presence of… Expand
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Highly Cited
2000
Highly Cited
2000
α‐Synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the α‐synuclein gene are responsible… Expand
Highly Cited
1999
Highly Cited
1999
Parkinson disease (PD) is a neurodegenerative disease characterized by tremor, bradykinesia, rigidity and postural instability… Expand
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Highly Cited
1999
Highly Cited
1999
Parkinson disease (PD) is a neurodegenerative disease characterized by tremor, bradykinesia, rigidity and postural instability… Expand