Synphilin-1

Known as: Alpha-Synuclein-Interacting Protein, Sph1 
Synphilin-1 (919 aa, ~100 kDa) is encoded by the human SNCAIP gene. This protein is involved in the modulation of ubiquitin ligase activity.
National Institutes of Health

Papers overview

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2010
2010
alpha-Synuclein (alpha-Syn) is the major component of Lewy bodies (LBs) deposited in the brains of patients with Parkinson's… (More)
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Highly Cited
2009
Highly Cited
2009
Mutations in PARKIN, pten-induced putative kinase 1 (PINK1), and DJ-1 are individually linked to autosomal recessive early-onset… (More)
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Highly Cited
2005
Highly Cited
2005
It is widely accepted that the familial Parkinson's disease (PD)-linked gene product, parkin, functions as a ubiquitin ligase… (More)
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Highly Cited
2004
Highly Cited
2004
Lewy bodies (LBs), which are the hallmark pathologic features of Parkinson's disease and of dementia with LBs, have several… (More)
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2004
Highly Cited
2004
Parkinson's disease (PD) is a neurodegenerative disease characterized by Lewy body formation and death of dopaminergic neurons… (More)
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2003
2003
Parkinson's disease (PD) is a neurodegenerative disease characterized by loss of nigra dopaminergic neurons. Lewy bodies (LBs… (More)
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2002
2002
α-Synuclein is a major component of Lewy bodies (LB) in Parkinson's disease (PD) and dementia with LB (DLB), as well as of glial… (More)
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Highly Cited
2001
Highly Cited
2001
Parkinson disease is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons and the presence of… (More)
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Highly Cited
2000
Highly Cited
2000
Alpha-synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the alpha-synuclein gene are… (More)
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1999
Highly Cited
1999
Parkinson disease (PD) is a neurodegenerative disease characterized by tremor, bradykinesia, rigidity and postural instability… (More)
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