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Synphilin-1

Known as: Alpha-Synuclein-Interacting Protein, Sph1 
Synphilin-1 (919 aa, ~100 kDa) is encoded by the human SNCAIP gene. This protein is involved in the modulation of ubiquitin ligase activity.
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Alzheimer's and Parkinson's diseases are the most common neurodegenerative diseases. They are characterized by protein aggregates… Expand
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Highly Cited
2009
Highly Cited
2009
Mutations in PARKIN, pten-induced putative kinase 1 (PINK1), and DJ-1 are individually linked to autosomal recessive early-onset… Expand
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Highly Cited
2005
Highly Cited
2005
It is widely accepted that the familial Parkinson's disease (PD)-linked gene product, parkin, functions as a ubiquitin ligase… Expand
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Highly Cited
2004
Highly Cited
2004
Lewy bodies (LBs), which are the hallmark pathologic features of Parkinson's disease and of dementia with LBs, have several… Expand
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Highly Cited
2003
Highly Cited
2003
Loss-of-function mutations in parkin are the major cause of early-onset familial Parkinson's disease. To investigate the… Expand
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Highly Cited
2002
Highly Cited
2002
Type I ubiquitin-like proteins constitute a family of protein modifiers. Here we report the identification of a posttranslational… Expand
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Highly Cited
2001
Highly Cited
2001
Parkinson disease is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons and the presence of… Expand
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Highly Cited
2000
Highly Cited
2000
α‐Synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the α‐synuclein gene are responsible… Expand
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Highly Cited
1999
Highly Cited
1999
Parkinson disease (PD) is a neurodegenerative disease characterized by tremor, bradykinesia, rigidity and postural instability… Expand
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Highly Cited
1999
Highly Cited
1999
Parkinson disease (PD) is a neurodegenerative disease characterized by tremor, bradykinesia, rigidity and postural instability… Expand
Is this relevant?