Skip to search formSkip to main contentSkip to account menu

Synphilin-1

Known as: Alpha-Synuclein-Interacting Protein, Sph1 
Synphilin-1 (919 aa, ~100 kDa) is encoded by the human SNCAIP gene. This protein is involved in the modulation of ubiquitin ligase activity.
National Institutes of Health

Related topics

Related topics

8 relations
Ankyrin RepeatCell NucleolusCytoplasmGenes, Regulator

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Aggresome formation and segregation of inclusions influence toxicity of α-synuclein and synphilin-1 in yeast.
PD (Parkinson's disease) is a neurodegenerative disorder, caused by a selective loss of dopaminergic neurons in the substantia… 
Highly Cited
2008
Highly Cited
2008
Autophagy-mediated clearance of aggresomes is not a universal phenomenon.
Aggresomes are juxtanuclear inclusion bodies that have been proposed to act as staging grounds for the disposal of protein… 
Highly Cited
2007
Highly Cited
2007
The proteasomal subunit S6 ATPase is a novel synphilin‐1 interacting protein—implications for Parkinson's disease
Synphilin‐1 is linked to Parkinson's disease (PD), based on its role as an alpha‐synuclein (PARK1)‐interacting protein and… 
2006
2006
Synphilin-1A: an aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from alpha-synucleinopathy patients.
alpha-Synucleinopathies are a group of neurological disorders characterized by the presence of intracellular inclusion bodies… 
2005
2005
Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation.
alpha-Synuclein is known to play a major role in the pathogenesis of Parkinson disease. We previously identified synphilin-1 as… 
Highly Cited
2004
Highly Cited
2004
Casein Kinase II-mediated Phosphorylation Regulates α-Synuclein/Synphilin-1 Interaction and Inclusion Body Formation*
α-Synuclein is a phosphoprotein that accumulates as a major component of Lewy bodies in the brains of patients with Parkinson… 
Highly Cited
2003
Highly Cited
2003
Dorfin Localizes to Lewy Bodies and Ubiquitylates Synphilin-1*
Parkinson's disease (PD) is a neurodegenerative disease characterized by loss of nigra dopaminergic neurons. Lewy bodies (LBs… 
2001
2001
Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations.
alpha-Synuclein is a major component of Lewy bodies, a neuropathological feature of Parkinson's disease. Two alpha-synuclein… 
2001
2001
Linking ubiquitin, parkin and synphilin-1
One neuronal characteristic of Parkinson disease is the presence of Lewy bodies–intracytoplasmic accumulations of protein. A new… 
Highly Cited
1999
Highly Cited
1999
Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions.
Parkinson disease (PD) is a neurodegenerative disease characterized by tremor, bradykinesia, rigidity and postural instability… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)