FAQ

Survival Motor Neuron Protein

Known as: Component of Gems 1, Gemin-1 
Survival motor neuron protein (294 aa, ~32 kDa) is encoded by the human SMN1 and SMN2 genes. This protein plays a role in the assembly of small… (More)

Topic mentions per year

Topic mentions per year

2008-2017
024620082017

Related topics

Related topics

9 relations
CytoplasmGenes, RegulatorNucleoplasmProline-Rich Domain
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Survival Motor Neuron Protein
Cytoplasm
Genes, Regulator
Sarcomeres
protein protein interaction
RNA Splicing

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Investigation of New Morpholino Oligomers to Increase Survival Motor Neuron Protein Levels in Spinal Muscular Atrophy
Spinal muscular atrophy (SMA) is an autosomal-recessive childhood motor neuron disease and the main genetic cause of infant… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2018
2018
Motor neuron disease: Positive trial results published for ground-breaking SMA therapies
The results from two clinical trials of novel therapies for spinal muscular atrophy (SMA) have been published in the New England… (More)
Is this relevant?
2017
2017
Gestational Age-Dependent Increase of Survival Motor Neuron Protein in Umbilical Cord-Derived Mesenchymal Stem Cells
BACKGROUND Spinal muscular atrophy (SMA) is the most common genetic neurological disease leading to infant death. It is caused by… (More)
Is this relevant?
2017
2017
Survival Motor Neuron Protein is Released from Cells in Exosomes: A Potential Biomarker for Spinal Muscular Atrophy
Spinal muscular atrophy (SMA) is caused by homozygous mutation of the survival motor neuron 1 (SMN1) gene. Disease severity… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2017
2017
Regulation of Survival Motor Neuron Protein by the Nuclear Factor-Kappa B Pathway in Mouse Spinal Cord Motoneurons
Survival motor neuron (SMN) protein deficiency causes the genetic neuromuscular disorder spinal muscular atrophy (SMA… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2016
2016
Imaging Flow Cytometry Analysis to Identify Differences of Survival Motor Neuron Protein Expression in Patients With Spinal Muscular Atrophy.
BACKGROUND Spinal muscular atrophy is a neurodegenerative disorder caused by the deficient expression of survival motor neuron… (More)
Is this relevant?
2015
2015
Salbutamol inhibits ubiquitin-mediated survival motor neuron protein degradation in spinal muscular atrophy cells
Spinal muscular atrophy (SMA) is a common autosomal recessive neuromuscular disorder that is currently incurable. SMA is caused… (More)
Is this relevant?
2013
2013
Nanomolar Naloxone Attenuates Neurotoxicity Induced by Oxidative Stress and Survival Motor Neuron Protein Deficiency
Oxidative stress and survival motor neuron (Smn) protein deficiency are the major causes of motor neuronal death. Naloxone… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
2012
2012
Evaluation of Peripheral Blood Mononuclear Cell Processing and Analysis for Survival Motor Neuron Protein
OBJECTIVES Survival Motor Neuron (SMN) protein levels may become key pharmacodynamic (PD) markers in spinal muscular atrophy (SMA… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
2011
2011
Survival Motor Neuron Protein Regulates Stem Cell Division, Proliferation, and Differentiation in Drosophila
Spinal muscular atrophy is a severe neurogenic disease that is caused by mutations in the human survival motor neuron 1 (SMN1… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?