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Gallic acid, a major component of Toona sinensis leaf extracts, contains a ROS-mediated anti-cancer activity in human prostate cancer cells.
Prostate cancer, the most frequently diagnosed malignancy in elderly males of the United States, has become a major health issue in Asia. Previous studies have demonstrated that leaf extracts of… Expand
Influenza A (H(1)N(1)) Antiviral and Cytotoxic Agents from Ferula assa-foetida.
Two new sesquiterpene coumarins, designated 5'-acetoxy-8'-hydroxyumbelliprenin (1) and 10'R-acetoxy-11'-hydroxyumbelliprenin (2), and a new diterpene, 15-hydroxy-6-en-dehydroabietic acid (3), along… Expand
The Constituents of Cananga odorata
Sixteen compounds, (+)-ushinsunine-β-N-oxide (1), cleistopholine (2), liriodenine (3), (-)-anonaine (4), (+)-nornuciferine (5), (+)-N-acetylnornuciferine (6), (-)-ushinsunine (7), (-)-norushinsunine… Expand
Historic perspectives on Annonaceous acetogenins from the chemical bench to preclinical trials.
Studies on the Annonaceous acetogenins began after the first cytotoxic acetogenin, uvaricin, was isolated in 1982. This attractive finding made many medicinal and natural product chemists direct… Expand
Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties
For their various bioactivities, biomaterials derived from marine algae are important ingredients in many products, such as cosmetics and drugs for treating cancer and other diseases. This… Expand
Automatic Morphological Subtyping Reveals New Roles of Caspases in Mitochondrial Dynamics
- Jyh-Ying Peng, Chung-Chih Lin, +8 authors Chun-Nan Hsu
- Biology, Medicine
- PLoS Comput. Biol.
- 1 October 2011
We discovered six morphological subtypes of mitochondria for objective quantification of mitochondrial morphology. Expand
Cytotoxic constituents of the stem bark of Neolitsea acuminatissima.
Three new eudesmanolide sesquiterpenes, neolitacumone A-C (1-3), and one new benzylisoquinoline alkaloid, neolitacumonine (5), along with 27 known compounds were isolated from the stem bark of… Expand
Anti-AIDS agents. 48.(1) Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis.
A new triterpenoid named melliferone (1), three known triterpenoids, moronic acid (2), anwuweizonic acid (3), and betulonic acid (4), and four known aromatic compounds (5-8) were isolated from… Expand
Recent research and development of Antrodia cinnamomea.
Medicinal mushrooms have attracted much attention recently owing to their potent therapeutic activity, especially as chemopreventive and immunomodulatory agents. Antrodia cinnamomea is a treasured… Expand
Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria
- Chin-Chung Wu, Mei-Ling Chan, Wen-Ying Chen, C. Tsai, F. Chang, Y. Wu
- Biology, Medicine
- Molecular Cancer Therapeutics
- 1 August 2005
Pristimerin, a naturally occurring triterpenoid, has been shown to cause cytotoxicity in several cancer cell lines. However, the mechanism for the cytotoxic effect of pristimerin was never explored.… Expand