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Stem Cell Factor

Known as: stem cell factor (SCF), Stem Cell Factor [Chemical/Ingredient], c kit Ligand 
A hematopoietic growth factor and the ligand of the cell surface c-kit protein (PROTO-ONCOGENE PROTEINS C-KIT). It is expressed during embryogenesis… 
National Institutes of Health

Related topics

Related topics

21 relations

Broader (2)

Hematopoietic Cell Growth Factorscytokine
IL3 geneIn BloodInterleukin-3KITLG gene

Narrower (4)

Kit Ligand, humanancestimhematopoietic stem cell-chemotactic factorkitlga protein, zebrafish

Papers overview

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Highly Cited
1999
Highly Cited
1999
Stem cell factor is localized in, released from, and cleaved by human mast cells.
Stem cell factor (SCF) is the most important cytokine regulating human mast cell growth and functions. The immunogold technique… 
Highly Cited
1998
Highly Cited
1998
Human mast cells express stem cell factor
Stem cell factor (SCF) is a major cytokine regulator of mast cell growth and function. The present study demonstrates that human… 
Highly Cited
1997
Highly Cited
1997
Differential regulation of mast cell function by IL-10 and stem cell factor.
In the development of rodent mast cells (MC), IL-10 significantly enhances the growth factor activity of stem cell factor (SCF… 
Highly Cited
1995
Highly Cited
1995
Steel factor (c-kit ligand) promotes the survival of hematopoietic stem/progenitor cells in the absence of cell division.
It is known that the majority of primitive hematopoietic progenitors are in a noncycling quiescent state. In addition, normal… 
Highly Cited
1995
Highly Cited
1995
Quantitation of the quiescent fraction of long-term culture-initiating cells in normal human blood and marrow and the kinetics of their growth factor-stimulated entry into S-phase in vitro.
A method for quantitating the proportion of cycling long-term culture-initiating cells (LTC-IC) in heterogeneous populations of… 
Highly Cited
1994
Highly Cited
1994
Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins.
Highly Cited
1994
Highly Cited
1994
Effects of interleukin-3 and c-kit ligand on the survival of various classes of human hematopoietic progenitor cells.
We examined the effects of interleukin-3 (IL-3) and c-kit ligand (KL) on the survival of differentiated hematopoietic progenitor… 
Highly Cited
1993
Highly Cited
1993
The in vivo role of stem cell factor (c‐kit ligand) on mastocytosis and host protective immunity to the intestinal nematode Trichinella spiralis in mice
The role of stem cell factor (SCF) in the generation of intestinal mast cell hyperplasia and host protective immunity following… 
Highly Cited
1993
Highly Cited
1993
Expansion and Differentiation of Human Hematopoietic Cells from Static Cultures through Small‐Scale Bioreactors
Maintenance of the progenitor cells responsible for hematopoiesis has generally been accomplished using a feeder layer of stromal… 
Highly Cited
1981
Highly Cited
1981
Long-term in vitro culture of murine mast cells. II. Purification of a mast cell growth factor and its dissociation from TCGF.
Procedures are described for the isolation of a mast cell growth factor (MCGF) from medium conditioned by mitogen-activated… 
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