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Spondyloepimetaphyseal Dysplasia, Aggrecan Type

Known as: SEMD, Aggrecan Type 
National Institutes of Health

Related topics

Related topics

3 relations
ACAN, ASP2267ASN

Broader (2)

Bone Diseases, DevelopmentalCraniofacial Abnormalities

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
The role of cartilage glycosaminoglycan structure in gagCEST
Glycosaminoglycan (GAG) chemical exchange saturation transfer (gagCEST) is a potential method for cartilage quality assessment… 
Highly Cited
2015
Highly Cited
2015
Interleukin‐1 Acts via the JNK‐2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes
Aggrecan enables articular cartilage to bear load and resist compression. Aggrecan loss occurs early in osteoarthritis and… 
2010
2010
Quantification of aggrecan fragments in synovial fluid and urine using a high-throughput LC / MS / MS assay
INTRODUCTION: Aggrecanase (ADAMTS-4/-5)-mediated degradation of the aggrecan core protein is a key pathological event in… 
2010
2010
IONIC EFFECTS AND SELF-ASSEMBLY IN THE SOLUTION OF THE BIOPOLYMER AGGRECAN
It is noteworthy that degradative changes in the size and structure of aggrecan become more progressive with age. This process… 
2006
2006
Cartilage elasticity resides in shape module decoran and aggrecan sumps of damping fluid: implications in osteoarthrosis
Cartilage ultrastructure is based on collagen fibrils tied together by proteoglycans (PGs). Interfibrillar orthogonal PG bridges… 
2005
2005
Products resulting from cleavage of the interglobular domain of aggrecan in samples of synovial fluid collected from dogs with early- and late-stage osteoarthritis.
OBJECTIVE To investigate interglobular domain (IGD) cleavage of aggrecan in dogs with naturally developing osteoarthritis (OA… 
Highly Cited
2005
Highly Cited
2005
Lack of tissue inhibitor of metalloproteinases-3 results in an enhanced inflammatory response in antigen-induced arthritis.
2002
2002
Tensile Loading Promotes Fibrochondrocyte Differentiation of Mesenchymal Progenitors and Initial Development of Engineered Fibrocartilage Constructs
Introduction: Bone marrow stromal cells (BMSCs) are an attractive cell source for fibrocartilage repair due to their multipotency… 
1996
1996
Changes in cartilage proteoglycan aggrecan after intra-articular injection of interleukin-1 in rabbits: studies of synovial fluid and articular cartilage.
OBJECTIVE: To determine how acute but transient inflammation affects the cartilage proteoglycan aggrecan and the value of… 
Highly Cited
1993
Highly Cited
1993
Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain.
The actions of recombinant human fibroblast collagenase (MMP1), purified polymorphonuclear leucocyte collagenase (MMP8) and their… 
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