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Recent advances in intracellular staining techniques, cytometer technology, fluorescent reagents, and antibody production have… Expand The imidazoquinoline compounds imiquimod and R-848 are low-molecular-weight immune response modifiers that can induce the… Expand DNA from bacteria has stimulatory effects on mammalian immune cells, which depend on the presence of unmethylated CpG… Expand Bone marrow–derived antigen-presenting cells (APCs) take up cell-associated antigens and present them in the context of major… Expand Mutation of Caspase 9 (Casp9) results in embryonic lethality and defective brain development associated with decreased apoptosis… Expand Mice homozygous for lpr (lymphoproliferation) or gld (generalized lymphoproliferative disease) develop lymphadenopathy and suffer… Expand The Fas antigen (Fas) belongs to the tumor necrosis factor (TNF)/nerve growth factor receptor family, and it mediates apoptosis… Expand Interferon-gamma (IFN-gamma) is a pleiotrophic cytokine with immunomodulatory effects on a variety of immune cells. Mice with a… Expand A cytokine that can synergize with interleukin 2 to activate cytotoxic lymphocytes was purified to homogeneity. The protein… Expand We investigated the antigen specificity and presentation requirements for inactivation of T lymphocytes in vitro and in vivo. In… Expand