Spinal Muscular Atrophy

Known as: Spinal Amyotrophies, atrophy spinal muscular, Spinal Amyotrophy 
A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually… (More)

Topic mentions per year

Topic mentions per year

1945-2018
050019452017

Papers overview

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Review
2016
Review
2016
Spinal muscular atrophy (SMA) is an autosomal recessive motor neuron disease with a high incidence and is the most common genetic… (More)
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Review
2016
Review
2016
RNA therapeutics refers to the use of oligonucleotides to target primarily ribonucleic acids (RNA) for therapeutic efforts or in… (More)
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Review
2015
Review
2015
Spinal muscular atrophy (SMA) is a major neurodegenerative disorder of children and infants. SMA is primarily caused by low… (More)
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Review
2014
Review
2014
Spinal muscular atrophy (SMA) is a leading genetic cause of infant mortality. The disease originates from low levels of SMN… (More)
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Highly Cited
2009
Highly Cited
2009
Spinal muscular atrophy is one of the most common inherited forms of neurological disease leading to infant mortality. Patients… (More)
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Highly Cited
2000
Highly Cited
2000
The survival motor neuron gene is present in humans in a telomeric copy, SMN1, and several centromeric copies, SMN2. Homozygous… (More)
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Highly Cited
1999
Highly Cited
1999
SMN1 and SMN2 (survival motor neuron) encode identical proteins. A critical question is why only the homozygous loss of SMN1, and… (More)
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Highly Cited
1997
Highly Cited
1997
The 38 kDa survival motor neuron (SMN) protein is encoded by two ubiquitously expressed genes: telomeric SMN (SMN(T)) and… (More)
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Highly Cited
1997
Highly Cited
1997
Spinal muscular atrophy (SMA) is a common autosomal recessive neuromuscular disorder characterized by degeneration of motor… (More)
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Highly Cited
1995
Highly Cited
1995
Spinal muscular atrophy (SMA) is a common fatal autosomal recessive disorder characterized by degeneration of lower motor neurons… (More)
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