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Sphingosine N-Acyltransferase

Known as: Sphingosine N-Acyltransferase [Chemical/Ingredient], Fatty Acyl-CoA - Sphingosine Acyltransferase, Fatty Acyl CoA Sphingosine Acyltransferase 
An enzyme that catalyzes the acyltransferase of SPHINGOSINE to N-acylsphingosine using acyl-COENZYME A as donor and COENZYME A as acceptor. The… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1960-2017
0102019602017

Related topics

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12 relations

Narrower (5)

CERS1 protein, humanCERS2 protein, humanCERS5 protein, humanCERS6 protein, human
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In BloodProcess of secretionantagonists & inhibitorschemical synthesis
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Sphingosine N-Acyltransferase
physiological aspects
In Blood
chemical synthesis
standards characteristics
Process of secretion

Papers overview

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Highly Cited
2003
Highly Cited
2003
Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function.
Glucotoxicity and lipotoxicity contribute to the impaired beta-cell function observed in type 2 diabetes. Here we examine the… (More)
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Highly Cited
2003
Highly Cited
2003
Sphingosine kinase 2 is a nuclear protein and inhibits DNA synthesis.
Sphingosine kinase-1 (SPHK1) is a key enzyme catalyzing the formation of an important bioactive lipid messenger, sphingosine 1… (More)
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Highly Cited
2001
Highly Cited
2001
Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function.
Glucotoxicity and lipotoxicity contribute to the impaired beta-cell function observed in type 2 diabetes. Here we examine the… (More)
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Highly Cited
2000
Highly Cited
2000
Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform.
Sphingosine-1-phosphate (SPP) has diverse biological functions acting inside cells as a second messenger to regulate… (More)
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Highly Cited
1998
Highly Cited
1998
Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.
Like obese humans, Zucker diabetic fatty (ZDF) rats exhibit early beta cell compensation for insulin resistance (4-fold beta cell… (More)
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Highly Cited
1998
Highly Cited
1998
Molecular cloning and functional characterization of murine sphingosine kinase.
Sphingosine-1-phosphate (SPP) is a novel lipid messenger that has dual function. Intracellularly it regulates proliferation and… (More)
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1998
1998
Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction
Sphingosine N-acyltransferase (ceramide synthase, E.C. 2.3.1.24) was solubilized from bovine liver mitochondrion-rich fraction… (More)
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Highly Cited
1991
Highly Cited
1991
A novel fluorescent ceramide analogue for studying membrane traffic in animal cells: accumulation at the Golgi apparatus results in altered spectral properties of the sphingolipid precursor
A series of ceramide analogues bearing the fluorophore boron dipyrromethene difluoride (BODIPY) were synthesized and evaluated as… (More)
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Highly Cited
1989
Highly Cited
1989
The subcellular organization of Madin-Darby canine kidney cells during the formation of a polarized epithelium
Studies of the developing trophectoderm in the mouse embryo have shown that extensive cellular remodeling occurs during… (More)
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Highly Cited
1987
Highly Cited
1987
Sorting of sphingolipids in epithelial (Madin-Darby canine kidney) cells
To study the intracellular transport of newly synthesized sphingolipids in epithelial cells we have used a fluorescent ceramide… (More)
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