CERS5 protein, human

Known as: longevity assurance gene homolog 5, human, LAG1 Longevity Assurance Homolog 5 (S. cerevisiae), ceramide synthetase 5, human 
Ceramide synthase 5 (392 aa, ~46 kDa) is encoded by the human CERS5 gene. This protein is involved in apoptosis via the mitochondrial death pathway.
National Institutes of Health

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Highly Cited
2015
Highly Cited
2015
Impaired mitochondrial maintenance in disparate cell types is a shared hallmark of many human pathologies and ageing. How… (More)
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Highly Cited
2014
Highly Cited
2014
The purpose of these guidelines is to assist physicians in recommending, performing, interpreting and reporting the results of… (More)
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2014
2014
The ApoE gene is associated with the risk of Alzheimer or cardiovascular disease but its influence on exceptional longevity (EL… (More)
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Highly Cited
2012
Highly Cited
2012
Reduced insulin/IGF signaling extends lifespan in diverse species, including Drosophila melanogaster where the genome encodes… (More)
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2012
2012
Ceramide, the backbone of all sphingolipids, is synthesized by a family of ceramide synthases (CerS) that each use acyl-CoAs of… (More)
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2011
2011
The sphingolipid ceramide has been widely implicated in the regulation of programmed cell death or apoptosis. The accumulation of… (More)
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2011
2011
Many control theory based approaches have been proposed to provide QoS assurance in increasingly complex software systems. These… (More)
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Highly Cited
2007
Highly Cited
2007
In this study, quantitative isobologram studies showed that treatment with gemcitabine and doxorubicin, known inducers of… (More)
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2007
2007
Ceramide is synthesized in mammals by a family of ceramide synthases (CerS) each of which uses a relatively restricted set of… (More)
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Highly Cited
2006
Highly Cited
2006
To what extent are the determinants of aging in animal species universal? Insulin/insulin-like growth factor (IGF)-1 signaling… (More)
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