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Spectrin

Known as: Spectrin [Chemical/Ingredient], Spectrins 
A high molecular weight (220-250 kDa) water-soluble protein which can be extracted from erythrocyte ghosts in low ionic strength buffers. The protein… Expand
National Institutes of Health

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Related topics

24 relations

Broader (1)

Cytoskeletal Proteins

Narrower (15)

GTRAP41 protein, ratPLEKHG4 protein, humanSPHEROCYTOSIS, TYPE 3 (disorder)SPTBN1 protein, human
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Process of secretionagonistsantagonists & inhibitorsaspects of radiation effects
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Papers overview

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Highly Cited
2015
Highly Cited
2015
The Spectrin cytoskeleton regulates the Hippo signalling pathway
The Spectrin cytoskeleton is known to be polarised in epithelial cells, yet its role remains poorly understood. Here, we show… Expand
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2013
2013
The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route.
Mutations in the myosin VIIa gene cause Usher syndrome type IB (USH1B), characterized by deaf-blindness. A delay of opsin… Expand
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Highly Cited
2010
Highly Cited
2010
Metabolic remodeling of the human red blood cell membrane.
The remarkable deformability of the human red blood cell (RBC) results from the coupled dynamic response of the phospholipid… Expand
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Highly Cited
2006
Highly Cited
2006
Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton.
Paranodal junctions of myelinated nerve fibers are important for saltatory conduction and function as paracellular and membrane… Expand
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Highly Cited
2005
Highly Cited
2005
Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex.
Nephrin is a cell surface receptor of the Ig superfamily that localizes to slit diaphragms, the specialized junctions between the… Expand
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Highly Cited
2004
Highly Cited
2004
BetaIV spectrins are essential for membrane stability and the molecular organization of nodes of Ranvier.
High densities of sodium channels at nodes of Ranvier permit action potential conduction and depend on betaIV spectrins, a family… Expand
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Highly Cited
2003
Highly Cited
2003
Cooperativity in forced unfolding of tandem spectrin repeats.
Force-driven conformational changes provide a broad basis for protein extensibility, and multidomain proteins broaden the… Expand
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Highly Cited
2001
Highly Cited
2001
Drosophila alpha- and beta-spectrin mutations disrupt presynaptic neurotransmitter release.
Spectrins are plasma membrane-associated cytoskeletal proteins implicated in several aspects of synaptic development and function… Expand
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Review
1993
Review
1993
Erythroid and nonerythroid spectrins.
Recent developments have contributed important information to understanding the role of spectrins in the RBC membrane skeleton… Expand
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Highly Cited
1981
Highly Cited
1981
Self-assembly of spectrin oligomers in vitro: a basis for a dynamic cytoskeleton
Purified human erythrocyte spectrin is able to form large oligomeric species without the collaboration of any other proteins… Expand
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