FAQ

Spectrin

Known as: Spectrin [Chemical/Ingredient], Spectrins 
A high molecular weight (220-250 kDa) water-soluble protein which can be extracted from erythrocyte ghosts in low ionic strength buffers. The protein… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1969-2018
020406019692018

Related topics

Related topics

22 relations

Broader (1)

Cytoskeletal Proteins

Narrower (13)

PLEKHG4 protein, humanSPHEROCYTOSIS, TYPE 3 (disorder)SPTBN2 protein, humanalpha-Spectrin
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Process of secretionagonistsantagonists & inhibitorschemical synthesis
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Spectrin
physiological aspects
chemical synthesis
spectrin location
Cytoskeletal Proteins
fodrin

Papers overview

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Highly Cited
2007
Highly Cited
2007
βIV spectrin is recruited to axon initial segments and nodes of Ranvier by ankyrinG
High densities of ion channels at axon initial segments (AISs) and nodes of Ranvier are required for initiation, propagation, and… (More)
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Highly Cited
2005
Highly Cited
2005
Presynaptic Spectrin Is Essential for Synapse Stabilization
BACKGROUND Precise neural circuitry is established and maintained through a regulated balance of synapse stabilization and… (More)
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Highly Cited
2001
Highly Cited
2001
Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments
The axon initial segment is an excitable membrane highly enriched in voltage-gated sodium channels that integrates neuronal… (More)
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Highly Cited
2001
Highly Cited
2001
beta III spectrin binds to the Arp1 subunit of dynactin.
Cytoplasmic dynein is an intracellular motor responsible for endoplasmic reticulum-to-Golgi vesicle trafficking and retrograde… (More)
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Highly Cited
2000
Highly Cited
2000
βiv Spectrin, a New Spectrin Localized at Axon Initial Segments and Nodes of Ranvier in the Central and Peripheral Nervous System
We report the identification of betaIV spectrin, a novel spectrin isolated as an interactor of the receptor tyrosine phosphatase… (More)
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Highly Cited
1999
Highly Cited
1999
Single molecule force spectroscopy of spectrin repeats: low unfolding forces in helix bundles.
Spectrin repeats fold into triple helical coiled-coils comprising approximately 106 amino acid residues. Using an AFM-related… (More)
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Highly Cited
1996
Highly Cited
1996
Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis.
The cytoskeletal protein non-erythroid alpha-spectrin is well documented as an endogenous calpain substrate, especially under… (More)
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Highly Cited
1996
Highly Cited
1996
Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles
Centractin (Arp1), an actin-related protein, is a component of the dynactin complex. To investigate potential functions of the… (More)
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Highly Cited
1989
Highly Cited
1989
Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor
Addition of EGF to human carcinoma A-431 cells is known to induce membrane ruffling after approximately 2 min (Chinkers, M., J. A… (More)
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Highly Cited
1986
Highly Cited
1986
Brain spectrin(240/235) and brain spectrin(240/235E): two distinct spectrin subtypes with different locations within mammalian neural cells
Adult mouse brain contains at least two distinct spectrin subtypes, both consisting of 240-kD and 235-kD subunits. Brain spectrin… (More)
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