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Broad spectrum O-linked protein glycosylation in the human pathogen Neisseria gonorrhoeae
TLDR
Together, these findings reveal previously unrecognized commonalities linking O-linked protein glycosylation in distantly related life forms. Expand
The direct route: a simplified pathway for protein import into the mitochondrion of trypanosomes.
TLDR
What is known about the mitochondrial protein import pathway in T. brucei, how it compares with the process in humans, and how the distinguishing features seen in the parasite and humans promise new understanding of the mitochondrialprotein import process in all eukaryotes are reviewed are reviewed. Expand
Pentatricopeptide Repeat Proteins in Trypanosoma brucei Function in Mitochondrial Ribosomes
TLDR
The results show that a significant number of trypanosomal PPR proteins are individually essential for the maintenance and/or biogenesis of mitochondrial rRNAs. Expand
Mitochondrial Substrate Level Phosphorylation Is Essential for Growth of Procyclic Trypanosoma brucei *
TLDR
Results show that oxygen-independent substrate level phosphorylation either linked to the citric acid cycle or tied into acetate production is essential for growth of procyclic T. brucei, a situation that may reflect an adaptation to the partially hypoxic conditions in the insect host. Expand
Unique aspects of mitochondrial biogenesis in trypanosomatids.
  • A. Schneider
  • Biology, Medicine
  • International journal for parasitology
  • 1 November 2001
TLDR
Trypanosomatids belong to the earliest diverging branches of the eukaryotic evolutionary tree which have mitochondria and have life cycle stages exhibiting very different mitochondrial activities and can therefore serve as a model system for the regulation of mitochondrial biogenesis. Expand
Mitochondrial Preprotein Translocase of Trypanosomatids Has a Bacterial Origin
TLDR
Using a combination of bioinformatics and in vivo and in vitro studies, it is discovered that T. brucei likely employs a different import channel, termed ATOM (archaic translocase of the outer mitochondrial membrane), which mediates the import of nuclear-encoded proteins into mitochondria and is essential for viability of trypanosomes. Expand
Mitochondrial translation in absence of local tRNA aminoacylation and methionyl tRNAMet formylation in Apicomplexa
TLDR
This study reveals that aaRSs are either cytosolic, apicoplastic or shared between the two compartments by dual targeting but are absent from the mitochondrion of Apicomplexa, suggesting that tRNAs are very likely imported in their aminoacylated form. Expand
Distinct localization and cell cycle dependence of COOH terminally tyrosinolated alpha-tubulin in the microtubules of Trypanosoma brucei brucei
TLDR
The results indicate that the presence of tyrosinolated alpha-tubulin is a marker for newly formed microtubules in the parasitic hemoflagellate Trypanosoma Brucei brucei and this localization is subject to a temporal modulation that correlates strongly with progress of a cell through the cell cycle. Expand
The single mitochondrial porin of Trypanosoma brucei is the main metabolite transporter in the outer mitochondrial membrane.
TLDR
Results demonstrate that the mitochondria isolated from homozygous knockout cells did not produce adenosine-triphosphate in response to added substrates, but ATP production was restored by physical disruption of the outer membrane, demonstrating that the mitochondrial porin identified in T. brucei is the main metabolite channel in the outer membranes and therefore the functional orthologue of VDAC. Expand
Evolution of macromolecular import pathways in mitochondria, hydrogenosomes and mitosomes
TLDR
How the processes of protein import and tRNA import relate to each other in an evolutionary context are discussed using a recently revised eukaryotic phylogeny as a framework. Expand
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