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Sparsomycin

Known as: 2-Propenamide, N-(1-(hydroxymethyl)-2-(((methylthio)methyl)sulfinyl)ethyl)-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-, (R-(R*,S*-(E)))-, Sparsomycin [Chemical/Ingredient] 
An antitumor antibiotic produced by Streptomyces sparsogenes. It inhibits protein synthesis in 70S and 80S ribosomal systems.
National Institutes of Health

Related topics

Related topics

13 relations

Broader (2)

Antibiotics, AntineoplasticProtein Synthesis Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (4)

MDL 20828deshydroxysparsomycinethyldeshydroxysparsomycinoctylsparsomycin

Papers overview

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1989
1989
Lipophilic analogues of sparsomycin as strong inhibitors of protein synthesis and tumor growth: a structure-activity relationship study.
Fourteen derivatives of sparsomycin (1) were synthesized. Six of them were prepared following a novel synthetic route starting… 
Highly Cited
1985
Highly Cited
1985
A short route to chiral sulfoxides using titanium-mediated asymmetric oxidation
Abstract 
1984
1984
Structure-activity relationships of sparsomycin and its analogues. Octylsparsomycin: the first analogue more active than sparsomycin.
Nine analogues of sparsomycin were synthesized, and their cytostatic activity was studied in an in vitro clonogenic L1210 assay… 
1980
1980
Ribosomal resistance to the 12,13-epoxytrichothecene antibiotics in the producing organism Myrothecium verrucaria.
An extract of Myrothecium verrucaria, a fungus which produces a range of 12,13-epoxytrichothecene toxins, was found to be… 
1978
1978
Effect of sparsomycin analogues on the puromycin-peptidyl transferase reaction on ribosomes.
Sparsomycin analogues in which the unique -S(O)CH2SCH3 moiety was replaced by a variety of more easily accessible side chains… 
1977
1977
Pyrimidinylpropenamides as antitumor agents. Analogues of the antibiotic sparsomycin.
A series of pyrimidinylpropenamides 9 and their oxidation products 10 was prepared, as analogues of sparsomycin (1), for… 
1975
1975
Inhibitors of polypeptide elongation on yeast polysomes.
Yeast polysomes are very active for amino acid incorporation when supplemented with elongation factors and the different… 
1970
1970
Peptide chain termination. VII. The ribosomal and release factor requirements for peptide release.
Release factors participate in release of fMet from fMet-tRNA . AUG . ribosome intermediates upon binding to ribosomes. This… 
1968
1968
The action of sparsomycin and gougerotin on virus growth.
Summary The incorporation of [14C]amino acids into the acid precipitable material of chick embryo fibroblasts was inhibited by… 
1966
1966
Toxic retinopathy following sparsomycin therapy.
This paper presents the clinical and histologic ocular findings of two patients who developed toxic retinal changes while…