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Sparsomycin

Known as: 2-Propenamide, N-(1-(hydroxymethyl)-2-(((methylthio)methyl)sulfinyl)ethyl)-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-, (R-(R*,S*-(E)))-, Sparsomycin [Chemical/Ingredient] 
An antitumor antibiotic produced by Streptomyces sparsogenes. It inhibits protein synthesis in 70S and 80S ribosomal systems.
National Institutes of Health

Related topics

Related topics

13 relations

Broader (2)

Antibiotics, AntineoplasticProtein Synthesis Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (4)

MDL 20828deshydroxysparsomycinethyldeshydroxysparsomycinoctylsparsomycin

Papers overview

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1989
1989
Lipophilic analogues of sparsomycin as strong inhibitors of protein synthesis and tumor growth: a structure-activity relationship study.
Fourteen derivatives of sparsomycin (1) were synthesized. Six of them were prepared following a novel synthetic route starting… 
1984
1984
Structure-activity relationships of sparsomycin and its analogues. Octylsparsomycin: the first analogue more active than sparsomycin.
Nine analogues of sparsomycin were synthesized, and their cytostatic activity was studied in an in vitro clonogenic L1210 assay… 
1980
1980
Initiation of reovirus transcription by inosine 5'-triphosphate and properties of 7-methylinosine-capped, inosine-substituted messenger ribonucleic acids.
Inosine 5'-triphosphate (ITP) can be utilized in place of guanosine 5'-triphosphate (GTP) for both the initiation and the… 
1979
1979
Antibiotic effects on the photoinduced affinity labeling of Escherichia coli ribosomes by puromycin.
The effect of ribosomal antibiotics on the photoinduced affinity labeling of Escherichia coli ribosomes by puromycin [Cooperman… 
1978
1978
Effect of sparsomycin analogues on the puromycin-peptidyl transferase reaction on ribosomes.
Sparsomycin analogues in which the unique -S(O)CH2SCH3 moiety was replaced by a variety of more easily accessible side chains… 
1978
1978
Inhibition, by selected antibiotics, of protein synthesis in cells growing in tissue cultures.
A large number of compounds including actinobolin, adrenochrome, amicetin, anisomycin, aurintricarboxylic acid, blasticidin S… 
1977
1977
Pyrimidinylpropenamides as antitumor agents. Analogues of the antibiotic sparsomycin.
A series of pyrimidinylpropenamides 9 and their oxidation products 10 was prepared, as analogues of sparsomycin (1), for… 
1975
1975
Inhibitors of polypeptide elongation on yeast polysomes.
Yeast polysomes are very active for amino acid incorporation when supplemented with elongation factors and the different… 
1968
1968
The action of sparsomycin and gougerotin on virus growth.
Summary The incorporation of [14C]amino acids into the acid precipitable material of chick embryo fibroblasts was inhibited by… 
1966
1966
Microbiological studies on the mechanism of action of sparsomycin.
A primary site of sparsomycin attack in Escherichia coli appears to be inhibition of synthesis of protein, which occurs at…