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Sparsomycin

Known as: 2-Propenamide, N-(1-(hydroxymethyl)-2-(((methylthio)methyl)sulfinyl)ethyl)-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-, (R-(R*,S*-(E)))-, Sparsomycin [Chemical/Ingredient] 
An antitumor antibiotic produced by Streptomyces sparsogenes. It inhibits protein synthesis in 70S and 80S ribosomal systems.
National Institutes of Health

Related topics

Related topics

13 relations

Broader (2)

Antibiotics, AntineoplasticProtein Synthesis Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (4)

MDL 20828deshydroxysparsomycinethyldeshydroxysparsomycinoctylsparsomycin

Papers overview

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Highly Cited
2003
Highly Cited
2003
Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit.
Highly Cited
2003
Highly Cited
2003
Catalysis of Ribosomal Translocation by Sparsomycin
During protein synthesis, transfer RNAs (tRNAs) are translocated from the aminoacyl to peptidyl to exit sites of the ribosome… 
Highly Cited
1977
Highly Cited
1977
Importance of 5'-terminal blocking structure to stabilize mRNA in eukaryotic protein synthesis.
The 7-methylguanylic acid residue confronting the 5'-terminal nucleotide of mRNA through two pyrophosphate linkages was… 
1974
1974
The sensitivity of rat liver and yeast mitochondrial ribosomes to inhibitors of protein synthesis.
Highly Cited
1973
Highly Cited
1973
Initiation of protein synthesis: evidence for messenger RNA-independent binding of methionyl-transfer RNA to the 40 S ribosomal subunit.
Review
1970
Review
1970
Studies on the formation of transfer ribonucleic acid-ribosome complexes. 8. Survey of the effect of antibiotics of N-acetyl-phenylalanyl-puromycin formation: possible mechanism of chloramphenicol…
Highly Cited
1969
Highly Cited
1969
Action of Sparsomycin on Ribosome-catalysed Peptidyl Transfer
Sparsomycin inhibits protein biosynthesis by inducing the formation of an inert complex between the peptidyl donor substrate and… 
Highly Cited
1969
Highly Cited
1969
Derepression of a proline transport system in Saccharomyces chevalieri by nitrogen starvation.
Highly Cited
1967
Highly Cited
1967
Effects of some inhibitors of protein synthesis on the binding of aminoacyl tRNA to ribosomal subunits.
Highly Cited
1966
Highly Cited
1966
Inhibition of protein synthesis in reticulocytes by antibiotics. I. Effects on polysomes.
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