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Sparsomycin

Known as: 2-Propenamide, N-(1-(hydroxymethyl)-2-(((methylthio)methyl)sulfinyl)ethyl)-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-, (R-(R*,S*-(E)))-, Sparsomycin [Chemical/Ingredient] 
An antitumor antibiotic produced by Streptomyces sparsogenes. It inhibits protein synthesis in 70S and 80S ribosomal systems.
National Institutes of Health

Related topics

Related topics

13 relations

Broader (2)

Antibiotics, AntineoplasticProtein Synthesis Inhibitors
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (4)

MDL 20828deshydroxysparsomycinethyldeshydroxysparsomycinoctylsparsomycin

Papers overview

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Highly Cited
1999
Highly Cited
1999
Direct crosslinking of the antitumor antibiotic sparsomycin, and its derivatives, to A2602 in the peptidyl transferase center of 23S-like rRNA within ribosome-tRNA complexes.
The antitumor antibiotic sparsomycin is a universal and potent inhibitor of peptide bond formation and selectively acts on… 
Highly Cited
1985
Highly Cited
1985
A short route to chiral sulfoxides using titanium-mediated asymmetric oxidation
Abstract 
Highly Cited
1984
Highly Cited
1984
Superinduction of human interleukin-2 messenger RNA by inhibitors of translation.
1980
1980
Binding of wheat germ ribosomes to bisulfite-modified reovirus messenger RNA: evidence for a scanning mechanism.
Highly Cited
1973
Highly Cited
1973
Initiation of protein synthesis: evidence for messenger RNA-independent binding of methionyl-transfer RNA to the 40 S ribosomal subunit.
1970
1970
Effect of inhibitors of protein synthesis on DNA formation in liver.
Highly Cited
1969
Highly Cited
1969
Action of Sparsomycin on Ribosome-catalysed Peptidyl Transfer
Sparsomycin inhibits protein biosynthesis by inducing the formation of an inert complex between the peptidyl donor substrate and… 
Highly Cited
1969
Highly Cited
1969
Derepression of a proline transport system in Saccharomyces chevalieri by nitrogen starvation.
1969
1969
Polyribosomes of Escherichia coli. II. Experiments to determine the in vivo distribution of polysomes, ribosomes and ribosomal subunits.
Highly Cited
1967
Highly Cited
1967
Effects of some inhibitors of protein synthesis on the binding of aminoacyl tRNA to ribosomal subunits.
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