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Sparsomycin

Known as: 2-Propenamide, N-(1-(hydroxymethyl)-2-(((methylthio)methyl)sulfinyl)ethyl)-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-, (R-(R*,S*-(E)))-, Sparsomycin [Chemical/Ingredient] 
An antitumor antibiotic produced by Streptomyces sparsogenes. It inhibits protein synthesis in 70S and 80S ribosomal systems.
National Institutes of Health

Papers overview

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2010
2010
The interactions of the 50S subunit of bacterial ribosome with antibiotic sparsomycin (SPS) and five analogs (AN) are… Expand
Highly Cited
2003
Highly Cited
2003
Structures of anisomycin, chloramphenicol, sparsomycin, blasticidin S, and virginiamycin M bound to the large ribosomal subunit… Expand
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Highly Cited
2003
Highly Cited
2003
During protein synthesis, transfer RNAs (tRNAs) are translocated from the aminoacyl to peptidyl to exit sites of the ribosome… Expand
Highly Cited
2003
Highly Cited
2003
Crystal structures of tRNA mimics complexed with the large ribosomal subunit of Deinococcus radiodurans indicate that remote… Expand
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Highly Cited
2002
Highly Cited
2002
The large ribosomal subunit catalyzes peptide bond formation and will do so by using small aminoacyl- and peptidyl-RNA fragments… Expand
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Highly Cited
1977
Highly Cited
1977
The 7-methylguanylic acid residue confronting the 5'-terminal nucleotide of mRNA through two pyrophosphate linkages was… Expand
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Highly Cited
1977
Highly Cited
1977
The Cephalotaxus alkaloids harringtonine, homoharringtonine and isoharringtonine inhibit protein synthesis in eukaryotic cells… Expand
Highly Cited
1973
Highly Cited
1973
Abstract This paper shows that reticuloeyte lysates contain 40 S/Met-tRNA f complexes which are intermediates in the initiation… Expand
Highly Cited
1969
Highly Cited
1969
Sparsomycin inhibits protein biosynthesis by inducing the formation of an inert complex between the peptidyl donor substrate and… Expand
Highly Cited
1969
Highly Cited
1969
Abstract Sites of cycloheximide action on protein synthesis were examined using a cell-free system prepared from rat liver. If… Expand
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