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Somatic Cell Genetics

Various methods for gene function studies that rely on the use of cells in culture.
National Institutes of Health

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Highly Cited
2015
Highly Cited
2015
The CRISPR/Cas9 system has revolutionized mammalian somatic cell genetics. Genome-wide functional screens using CRISPR/Cas9… Expand
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Highly Cited
2001
Highly Cited
2001
Global patterns of human DNA sequence variation (haplotypes) defined by common single nucleotide polymorphisms (SNPs) have… Expand
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Highly Cited
2000
Highly Cited
2000
Control of mRNA stability is critical for expression of short-lived transcripts from cytokines and proto-oncogenes. Regulation… Expand
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Review
1999
Review
1999
A number of recent advances have significantly facilitated gene targeting in somatic cells. Gene targeting can now be performed… Expand
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Highly Cited
1987
Highly Cited
1987
Embryonal stem (ES) cell lines, established in culture from peri-implantation mouse blastocysts1–3, can colonize both the somatic… Expand
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1984
1984
The methods of somatic cell genetics and molecular hybridization were applied to a panel of mouse X rat hepatocyte hybrids… Expand
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Highly Cited
1980
Highly Cited
1980
Plant regeneration from totipotent cultured cells or protoplasts is a prerequisite for the often proposed genetic modification of… Expand
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Highly Cited
1978
Highly Cited
1978
Antibody-secreting hybrid cells have been derived from a fusion between mouse myeloma cells and spleen cells from a mouse… Expand
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1973
1973
Techniques for the study of somatic cell genetics, and particularly those involving the expression of enzyme markers in hybrid… Expand
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1973
1973
SOMATIC cell populations can be used for genetic analysis because of the occurrence of parasexual events1. Genetically dilferent… Expand
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