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Somatic Cell Genetics

Various methods for gene function studies that rely on the use of cells in culture.
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
Karyotype analysis utilizing differentially stained constitutive heterochromatin of human and murine chromosomes
Constitutive heterochromatin of chromosomes can be visualized utilizing a new differential staining technique which was… 
1994
1994
How variable is a spontaneous mutation rate in cultured mammalian cells?
Review
1992
Review
1992
Using fluorescence in situ hybridization (FISH) in genome mapping.
Review
1990
Review
1990
Frontiers in mammalian cell culture.
For the past 60 years, fundamental discoveries in eukaryotic biology using mammalian cell cultures have been significant but… 
Highly Cited
1986
Highly Cited
1986
Functional expression of a human Na+/H+ antiporter gene transfected into antiporter-deficient mouse L cells.
To clone the gene for the human Na+/H+ antiporter, we first constructed a stable mouse LTK- cell line (LAP1) lacking Na+/H… 
Highly Cited
1984
Highly Cited
1984
Gene mapping in the rat by mouse-rat somatic cell hybridization: synteny of the albumin and alpha-fetoprotein genes and assignment to chromosome 14.
The methods of somatic cell genetics and molecular hybridization were applied to a panel of mouse X rat hepatocyte hybrids… 
Highly Cited
1979
Highly Cited
1979
Genetic mapping of the ecotropic murine leukemia virus-inducing locus of BALB/c mouse to chromosome 5.
By means of an approach that combined the techniques of somatic cell genetics and Mendelian breeding studies, the inducibility… 
Highly Cited
1978
Highly Cited
1978
A herpes simplex virus 1 integration site in the mouse genome defined by somatic cell genetic analysis
Highly Cited
1973
Highly Cited
1973
Linkage Analysis in Man by Somatic Cell Genetics
Techniques for the study of somatic cell genetics, and particularly those involving the expression of enzyme markers in hybrid… 
Highly Cited
1973
Highly Cited
1973
Assignment of nucleoside phosphorylase to D-14 and localization of X-linked loci in man by somatic cell genetics.
SOMATIC cell populations can be used for genetic analysis because of the occurrence of parasexual events1. Genetically dilferent… 
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