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Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.
A novel potential cell surface receptor of the tyrosine kinase gene family has been identified and characterized by molecular cloning. Its primary sequence is very similar to that of the human…
Insulin‐like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.
The complete primary structure of the human IGF‐I receptor from cloned cDNA is determined and the deduced sequence predicts a 1367 amino acid receptor precursor, including a 30‐residue signal peptide, which is removed during translocation of the nascent polypeptide chain.
Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.
- S. Ramamoorthy, A. Bauman, R. Blakely
- BiologyProceedings of the National Academy of Sciences…
- 15 March 1993
A Na(+)- and Cl(-)-coupled serotonin (5-hydroxytryptamine, 5HT) transporter is expressed on human neuronal, platelet, placental, and pulmonary membranes and sequence analysis reveals a 630-amino acid open reading frame bearing 92% identity to the cloned rat brain 5HT transporter.
Human proto‐oncogene c‐kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.
The results suggest that p145c‐kit functions as a cell surface receptor for an as yet unidentified ligand, and carboxy‐ and amino‐terminal truncations that occurred during the viral transduction process are likely to have generated the transformation potential of v‐kit.
Human Intestinal H+/Peptide Cotransporter
Ch Chromosomal assignment studies with somatic cell hybrid analysis and in situ hybridization have located the gene encoding the cloned human H+/peptide cotransporter to chromosome 13 q33→q34.
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors
The primary structure of the receptor for platelet-derived growth factor (PDGF), determined by means of cloning a cDNA that encodes the murine pre-PDGF receptor, is closely related to that of the…
Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression
Results suggest that mitosin may play an important role in mitotic-phase progression and Overexpression of N-terminally truncated mutants blocks cell cycle progression mainly at G2/M.
Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter.
The cloning of DNAhuman dopamine transporter gene has allowed establishment of a cell line stably expressing the human dopamine transporter and, for the first time, an extensive characterization of its pharmacology.
A transcript map of the newly defined 165 kb Wolf-Hirschhorn syndrome critical region.
This work uses a series of landmark cosmids to characterise a collection of WHS patient derived cell lines and provides the starting point to understand how multiple genes or other mechanisms can contribute to the complex phenotype associated with the Wolf-Hirschhorn syndrome.
Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways.
A new family of protein kinase C-related genes has been identified in bovine, human, and rat genomes that are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions.