Solute Carrier Family 22 Member 1

Known as: Organic Cation Transporter 1, SLC22A1, hOCT1 
Solute carrier family 22 member 1 (554 aa, ~61 kDa) is encoded by the human SLC22A1 gene. This protein is involved in bidirectional cation transport.
National Institutes of Health

Papers overview

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2013
2013
Although the prognosis of chronic myeloid leukemia (CML) patients treated with imatinib is good, many fail to develop an optimal… (More)
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Highly Cited
2009
Highly Cited
2009
Imatinib mesylate and nilotinib are highly effective at eradicating the majority of chronic myeloid leukemia (CML) cells; however… (More)
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Highly Cited
2008
Highly Cited
2008
Some chronic myeloid leukemia (CML) patients do not respond to imatinib, whereas others lose an initial response. To identify… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE The activity of imatinib in leukemia has recently been linked with expression of the organic cation transporter 1 (OCT1… (More)
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Highly Cited
2008
Highly Cited
2008
We have previously shown that imatinib uptake into chronic myeloid leukemia (CML) cells is dependent on human organic cation… (More)
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2005
2005
Human organic cation transporters (hOCTs) are expressed in organs of drug absorption and elimination and play an important role… (More)
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2005
2005
Organic cation transporters are important for the elimination of many drugs and toxins from the body. In the present study… (More)
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Highly Cited
2004
Highly Cited
2004
Organic cation transporter OCT1 (SLC22A1) plays an essential role in absorption, distribution, and excretion of various… (More)
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2003
2003
Organic cation transporters play a critical role in the elimination of therapeutic compounds in the liver and the kidney. We used… (More)
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Highly Cited
1998
Highly Cited
1998
Recently, a polyspecific organic cation transporter, hOCT1, was cloned from human liver. To date, limited studies examining the… (More)
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