Skip to search formSkip to main contentSkip to account menu

Solute Carrier Family 22 Member 1

Known as: Organic Cation Transporter 1, SLC22A1, hOCT1 
Solute carrier family 22 member 1 (554 aa, ~61 kDa) is encoded by the human SLC22A1 gene. This protein is involved in bidirectional cation transport.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Organic cation transporters (OCTs) of the solute carrier family (SLC) 22 and multidrug and toxin extrusion (MATE) transporters of… 
Highly Cited
2009
Highly Cited
2009
An important function of hepatocytes is the biotransformation and elimination of various drugs, many of which are organic cations… 
Highly Cited
2008
Highly Cited
2008
Some chronic myeloid leukemia (CML) patients do not respond to imatinib, whereas others lose an initial response. To identify… 
Highly Cited
2006
Highly Cited
2006
We have examined the role of the human organic cation transporters [hOCTs and human novel organic cation transporter (hOCTN… 
Highly Cited
2004
Highly Cited
2004
Imatinib is a tyrosine kinase inhibitor that is effective in the treatment of chronic myeloid leukemia (CML). Not all patients… 
Highly Cited
2002
Highly Cited
2002
Organic cation transporters (OCTs) are involved in the elimination of monoamines and cationic xenobiotics. To examine whether… 
Highly Cited
2001
Highly Cited
2001
ABSTRACT The polyspecific organic cation transporter 1 (OCT1 [SLC22A1]) mediates facilitated transport of small (hydrophilic… 
Highly Cited
1997
Highly Cited
1997
Previously we cloned a polyspecific transporter from rat (rOCT1) that is expressed in renal proximal tubules and hepatocytes and… 
Highly Cited
1997
Highly Cited
1997
Polyspecific organic cation transporters in the liver mediate the elimination of a wide array of endogenous amines and…