Solute Carrier Family 22 Member 1

Known as: Organic Cation Transporter 1, SLC22A1, hOCT1 
Solute carrier family 22 member 1 (554 aa, ~61 kDa) is encoded by the human SLC22A1 gene. This protein is involved in bidirectional cation transport.
National Institutes of Health

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16 relations
Biogenic Amine Metabolic ProcessCellular MembraneIntegral Membrane ProteinsIonophore activity
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Broader (1)

SLC22A4 gene

Papers overview

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2013
2013
The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia.
Although the prognosis of chronic myeloid leukemia (CML) patients treated with imatinib is good, many fail to develop an optimal… (More)
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Highly Cited
2009
Highly Cited
2009
Nilotinib concentration in cell lines and primary CD34+ chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters
Imatinib mesylate and nilotinib are highly effective at eradicating the majority of chronic myeloid leukemia (CML) cells; however… (More)
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Highly Cited
2008
Highly Cited
2008
Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia.
Some chronic myeloid leukemia (CML) patients do not respond to imatinib, whereas others lose an initial response. To identify… (More)
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Highly Cited
2008
Highly Cited
2008
Interaction of imatinib with human organic ion carriers.
PURPOSE The activity of imatinib in leukemia has recently been linked with expression of the organic cation transporter 1 (OCT1… (More)
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Highly Cited
2008
Highly Cited
2008
Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia.
We have previously shown that imatinib uptake into chronic myeloid leukemia (CML) cells is dependent on human organic cation… (More)
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2005
2005
Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3).
Human organic cation transporters (hOCTs) are expressed in organs of drug absorption and elimination and play an important role… (More)
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2005
2005
Molecular determinants of substrate/inhibitor binding to the human and rabbit renal organic cation transporters hOCT2 and rbOCT2.
Organic cation transporters are important for the elimination of many drugs and toxins from the body. In the present study… (More)
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Highly Cited
2004
Highly Cited
2004
Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions.
Organic cation transporter OCT1 (SLC22A1) plays an essential role in absorption, distribution, and excretion of various… (More)
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2003
2003
Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1.
Organic cation transporters play a critical role in the elimination of therapeutic compounds in the liver and the kidney. We used… (More)
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Highly Cited
1998
Highly Cited
1998
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
Recently, a polyspecific organic cation transporter, hOCT1, was cloned from human liver. To date, limited studies examining the… (More)
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