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Solute Carrier Family 22 Member 1
Known as:
Organic Cation Transporter 1
, SLC22A1
, hOCT1
Solute carrier family 22 member 1 (554 aa, ~61 kDa) is encoded by the human SLC22A1 gene. This protein is involved in bidirectional cation transport.
National Institutes of Health
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Related topics
Related topics
16 relations
Biogenic Amine Metabolic Process
Cellular Membrane
Integral Membrane Proteins
Ionophore activity
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Broader (1)
SLC22A4 gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Imatinib Affects the Expression of SLC22A1 in a Non-Linear Concentration-Dependent Manner Within 24 Hours
Sandhya Sreenivasan Tantuan
,
C. D. Viljoen
Medical science monitor basic research
2018
Corpus ID: 4564972
Background Imatinib is actively transported into cells by the organic cation transporter (OCT1), encoded by SLC22A1. As a result…
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2013
2013
Real-Time Polymerase Chain Reaction Testing for Quantitative Evaluation of hOCT1 and MDR1 Expression in Patients with Chronic Myeloid Leukemia Resistant to Imatinib
Saeed Solali
,
S. Kaviani
,
A. Movassaghpour
,
M. Aliparasti
2013
Corpus ID: 85728635
Objective: To study quantitative expression of the genes MDR1 and hOCT1 in 30 patients with chronic myeloid leukemia (CML) and 27…
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2012
2012
Release of intracellular calcium primes chronic myeloid leukaemia cells for tyrosine kinase inhibitor-induced apoptosis
S. Forchap
,
M. Pirmohamed
,
Richard E. Clark
Leukemia
2012
Corpus ID: 25314669
Imatinib is a substrate for hOCT1 (SLC22A1) and inhibitors of this influx transporter, such as amantadine and prazosin, have…
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2010
2010
Stereoselective binding of chiral ligands to single nucleotide polymorphisms of the human organic cation transporter-1 determined using cellular membrane affinity chromatography.
R. Moaddel
,
F. Bighi
,
R. Yamaguchi
,
S. Patel
,
S. Ravichandran
,
I. Wainer
Analytical Biochemistry
2010
Corpus ID: 32422022
2009
2009
Influence of the hOCT2 inhibitor cimetidine on the cellular accumulation and cytotoxicity of oxaliplatin.
I. Buss
,
G. Kalayda
,
P. Marqués-Gallego
,
J. Reedijk
,
U. Jaehde
International journal of clinical pharmacology…
2009
Corpus ID: 6335322
The platinum antitumor drug oxaliplatin, [Pt(DACH)(oxalate)] (Figure 1A), is frequently used in the treatment of colon and…
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2008
2008
Investigation of molecular recognition in biological systems using cellular membrane affinity chromatography.
I. Wainer
Chimica oggi
2008
Corpus ID: 12294450
Cellular membrane affinity chromatography (CMAC) columns have been created through the immobilization of cellular membrane…
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2005
2005
Development and characterization of an immobilized human organic cation transporter based liquid chromatographic stationary phase.
R. Moaddel
,
R. Yamaguchi
,
+4 authors
I. Wainer
Journal of chromatography. B, Analytical…
2005
Corpus ID: 34343091
2005
2005
Expression of the imatinib drug transporters hOCT1 and MDR1 levels determines imatinb response and development of BCR-ABL kinase mutations in chronic myeloid leukaemia (CML)
M. Pirmohamed
2005
Corpus ID: 69057550
2004
2004
PharmGKB Update: III. Genetic Variants of SLC22A1, Solute Carrier Family 22 (Organic Cation Transporter), Member 1
Y. Shu
,
M. Leabman
,
+10 authors
K. Giacomini
Pharmacological Reviews
2004
Corpus ID: 30057646
Category: Genotype PharmGKB Submission Number: PS203001 Date of Submission: June 16, 2003 Project: Pharmacogenetics of…
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2002
2002
Polymorphisms affecting function of the human organic cation transporter hOCT1 (SLC22A1): what are the consequences?
A. Schinkel
,
J. Jonker
Pharmacogenetics (London)
2002
Corpus ID: 3190041
It is well established that polymorphic genetic variations in some drug-metabolizing enzymes can dramatically affect the handling…
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