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Solute Carrier Family 22 Member 1

Known as: Organic Cation Transporter 1, SLC22A1, hOCT1 
Solute carrier family 22 member 1 (554 aa, ~61 kDa) is encoded by the human SLC22A1 gene. This protein is involved in bidirectional cation transport.
National Institutes of Health

Related topics

Related topics

16 relations
Biogenic Amine Metabolic ProcessCellular MembraneIntegral Membrane ProteinsIonophore activity
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Broader (1)

SLC22A4 gene

Papers overview

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Highly Cited
2009
Highly Cited
2009
Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver
An important function of hepatocytes is the biotransformation and elimination of various drugs, many of which are organic cations… Expand
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Highly Cited
2008
Highly Cited
2008
Expression of the Uptake Drug Transporter hOCT1 is an Important Clinical Determinant of the Response to Imatinib in Chronic Myeloid Leukemia
Some chronic myeloid leukemia (CML) patients do not respond to imatinib, whereas others lose an initial response. To identify… Expand
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Highly Cited
2008
Highly Cited
2008
Interaction of Imatinib with Human Organic Ion Carriers
Purpose: The activity of imatinib in leukemia has recently been linked with expression of the organic cation transporter 1 (OCT1… Expand
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Highly Cited
2006
Highly Cited
2006
Cisplatin and Oxaliplatin, but Not Carboplatin and Nedaplatin, Are Substrates for Human Organic Cation Transporters (SLC22A1–3 and Multidrug and Toxin Extrusion Family)
We have examined the role of the human organic cation transporters [hOCTs and human novel organic cation transporter (hOCTN… Expand
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Highly Cited
2005
Highly Cited
2005
Drug specificity and intestinal membrane localization of human organic cation transporters (OCT).
This study was performed to investigate which human organic cation transporter, hOCT1, hOCT2 or hOCT3, participates with regard… Expand
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Highly Cited
2004
Highly Cited
2004
Active transport of imatinib into and out of cells: implications for drug resistance.
Imatinib is a tyrosine kinase inhibitor that is effective in the treatment of chronic myeloid leukemia (CML). Not all patients… Expand
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Highly Cited
2002
Highly Cited
2002
Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3
Organic cation transporters (OCTs) are involved in the elimination of monoamines and cationic xenobiotics. To examine whether… Expand
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Highly Cited
2001
Highly Cited
2001
Reduced Hepatic Uptake and Intestinal Excretion of Organic Cations in Mice with a Targeted Disruption of the Organic Cation Transporter 1 (Oct1 [Slc22a1]) Gene
ABSTRACT The polyspecific organic cation transporter 1 (OCT1 [SLC22A1]) mediates facilitated transport of small (hydrophilic… Expand
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Highly Cited
1997
Highly Cited
1997
Cloning and characterization of two human polyspecific organic cation transporters.
Previously we cloned a polyspecific transporter from rat (rOCT1) that is expressed in renal proximal tubules and hepatocytes and… Expand
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Highly Cited
1997
Highly Cited
1997
Cloning and functional expression of a human liver organic cation transporter.
Polyspecific organic cation transporters in the liver mediate the elimination of a wide array of endogenous amines and… Expand
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