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Solute Carrier Family 22 Member 1
Known as:
Organic Cation Transporter 1
, SLC22A1
, hOCT1
Solute carrier family 22 member 1 (554 aa, ~61 kDa) is encoded by the human SLC22A1 gene. This protein is involved in bidirectional cation transport.
National Institutes of Health
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Related topics
Related topics
16 relations
Biogenic Amine Metabolic Process
Cellular Membrane
Integral Membrane Proteins
Ionophore activity
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Broader (1)
SLC22A4 gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy.
A. Nies
,
H. Koepsell
,
K. Damme
,
M. Schwab
Handbook of experimental pharmacology
2011
Corpus ID: 40516333
Organic cation transporters (OCTs) of the solute carrier family (SLC) 22 and multidrug and toxin extrusion (MATE) transporters of…
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Highly Cited
2009
Highly Cited
2009
Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver
A. Nies
,
H. Koepsell
,
+7 authors
E. Schaeffeler
Hepatology
2009
Corpus ID: 205870723
An important function of hepatocytes is the biotransformation and elimination of various drugs, many of which are organic cations…
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Highly Cited
2008
Highly Cited
2008
Expression of the Uptake Drug Transporter hOCT1 is an Important Clinical Determinant of the Response to Imatinib in Chronic Myeloid Leukemia
L. Wang
,
A. Giannoudis
,
S. Lane
,
P. Williamson
,
M. Pirmohamed
,
R. Clark
Clinical pharmacology and therapeutics
2008
Corpus ID: 10016666
Some chronic myeloid leukemia (CML) patients do not respond to imatinib, whereas others lose an initial response. To identify…
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Highly Cited
2006
Highly Cited
2006
Cisplatin and Oxaliplatin, but Not Carboplatin and Nedaplatin, Are Substrates for Human Organic Cation Transporters (SLC22A1–3 and Multidrug and Toxin Extrusion Family)
A. Yonezawa
,
S. Masuda
,
Sachiko Yokoo
,
T. Katsura
,
K. Inui
Journal of Pharmacology and Experimental…
2006
Corpus ID: 5972596
We have examined the role of the human organic cation transporters [hOCTs and human novel organic cation transporter (hOCTN…
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Highly Cited
2005
Highly Cited
2005
Drug specificity and intestinal membrane localization of human organic cation transporters (OCT).
Johanna Müller
,
K. Lips
,
L. Metzner
,
R. Neubert
,
H. Koepsell
,
M. Brandsch
Biochemical pharmacology
2005
Corpus ID: 29060716
Highly Cited
2004
Highly Cited
2004
Active transport of imatinib into and out of cells: implications for drug resistance.
Julia Thomas
,
Lihui Wang
,
R. Clark
,
M. Pirmohamed
Blood
2004
Corpus ID: 6914753
Imatinib is a tyrosine kinase inhibitor that is effective in the treatment of chronic myeloid leukemia (CML). Not all patients…
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Highly Cited
2002
Highly Cited
2002
Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3
M. Hayer-Zillgen
,
M. Brüss
,
H. Bönisch
British journal of pharmacology
2002
Corpus ID: 24181537
Organic cation transporters (OCTs) are involved in the elimination of monoamines and cationic xenobiotics. To examine whether…
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Highly Cited
2001
Highly Cited
2001
Reduced Hepatic Uptake and Intestinal Excretion of Organic Cations in Mice with a Targeted Disruption of the Organic Cation Transporter 1 (Oct1 [Slc22a1]) Gene
J. Jonker
,
E. Wagenaar
,
+4 authors
A. Schinkel
Molecular and Cellular Biology
2001
Corpus ID: 12898981
ABSTRACT The polyspecific organic cation transporter 1 (OCT1 [SLC22A1]) mediates facilitated transport of small (hydrophilic…
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Highly Cited
1997
Highly Cited
1997
Cloning and characterization of two human polyspecific organic cation transporters.
V. Gorboulev
,
J. Ulzheimer
,
+7 authors
H. Koepsell
DNA and cell biology
1997
Corpus ID: 20767326
Previously we cloned a polyspecific transporter from rat (rOCT1) that is expressed in renal proximal tubules and hepatocytes and…
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Highly Cited
1997
Highly Cited
1997
Cloning and functional expression of a human liver organic cation transporter.
L. Zhang
,
M. Dresser
,
A. Gray
,
S. Yost
,
S. Terashita
,
K. Giacomini
Molecular pharmacology
1997
Corpus ID: 30839969
Polyspecific organic cation transporters in the liver mediate the elimination of a wide array of endogenous amines and…
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