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Solute Carrier Family 22 Member 1

Known as: Organic Cation Transporter 1, SLC22A1, hOCT1 
Solute carrier family 22 member 1 (554 aa, ~61 kDa) is encoded by the human SLC22A1 gene. This protein is involved in bidirectional cation transport.
National Institutes of Health

Related topics

Related topics

16 relations
Biogenic Amine Metabolic ProcessCellular MembraneIntegral Membrane ProteinsIonophore activity

Broader (1)

SLC22A4 gene

Papers overview

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2018
2018
Imatinib Affects the Expression of SLC22A1 in a Non-Linear Concentration-Dependent Manner Within 24 Hours
Background Imatinib is actively transported into cells by the organic cation transporter (OCT1), encoded by SLC22A1. As a result… 
2013
2013
Real-Time Polymerase Chain Reaction Testing for Quantitative Evaluation of hOCT1 and MDR1 Expression in Patients with Chronic Myeloid Leukemia Resistant to Imatinib
Objective: To study quantitative expression of the genes MDR1 and hOCT1 in 30 patients with chronic myeloid leukemia (CML) and 27… 
2012
2012
Release of intracellular calcium primes chronic myeloid leukaemia cells for tyrosine kinase inhibitor-induced apoptosis
Imatinib is a substrate for hOCT1 (SLC22A1) and inhibitors of this influx transporter, such as amantadine and prazosin, have… 
2010
2010
Stereoselective binding of chiral ligands to single nucleotide polymorphisms of the human organic cation transporter-1 determined using cellular membrane affinity chromatography.
2009
2009
Influence of the hOCT2 inhibitor cimetidine on the cellular accumulation and cytotoxicity of oxaliplatin.
The platinum antitumor drug oxaliplatin, [Pt(DACH)(oxalate)] (Figure 1A), is frequently used in the treatment of colon and… 
2008
2008
Investigation of molecular recognition in biological systems using cellular membrane affinity chromatography.
Cellular membrane affinity chromatography (CMAC) columns have been created through the immobilization of cellular membrane… 
2005
2005
Development and characterization of an immobilized human organic cation transporter based liquid chromatographic stationary phase.
2005
2005
Expression of the imatinib drug transporters hOCT1 and MDR1 levels determines imatinb response and development of BCR-ABL kinase mutations in chronic myeloid leukaemia (CML)
2004
2004
PharmGKB Update: III. Genetic Variants of SLC22A1, Solute Carrier Family 22 (Organic Cation Transporter), Member 1
Category: Genotype PharmGKB Submission Number: PS203001 Date of Submission: June 16, 2003 Project: Pharmacogenetics of… 
2002
2002
Polymorphisms affecting function of the human organic cation transporter hOCT1 (SLC22A1): what are the consequences?
It is well established that polymorphic genetic variations in some drug-metabolizing enzymes can dramatically affect the handling… 
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