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Solute Carrier Family 22 Member 1

Known as: Organic Cation Transporter 1, SLC22A1, hOCT1 
Solute carrier family 22 member 1 (554 aa, ~61 kDa) is encoded by the human SLC22A1 gene. This protein is involved in bidirectional cation transport.
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
An important function of hepatocytes is the biotransformation and elimination of various drugs, many of which are organic cations… Expand
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Highly Cited
2008
Highly Cited
2008
Some chronic myeloid leukemia (CML) patients do not respond to imatinib, whereas others lose an initial response. To identify… Expand
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Highly Cited
2008
Highly Cited
2008
Purpose: The activity of imatinib in leukemia has recently been linked with expression of the organic cation transporter 1 (OCT1… Expand
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Highly Cited
2006
Highly Cited
2006
We have examined the role of the human organic cation transporters [hOCTs and human novel organic cation transporter (hOCTN… Expand
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Highly Cited
2005
Highly Cited
2005
This study was performed to investigate which human organic cation transporter, hOCT1, hOCT2 or hOCT3, participates with regard… Expand
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Highly Cited
2004
Highly Cited
2004
Imatinib is a tyrosine kinase inhibitor that is effective in the treatment of chronic myeloid leukemia (CML). Not all patients… Expand
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Highly Cited
2002
Highly Cited
2002
Organic cation transporters (OCTs) are involved in the elimination of monoamines and cationic xenobiotics. To examine whether… Expand
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Highly Cited
2001
Highly Cited
2001
ABSTRACT The polyspecific organic cation transporter 1 (OCT1 [SLC22A1]) mediates facilitated transport of small (hydrophilic… Expand
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Highly Cited
1997
Highly Cited
1997
Previously we cloned a polyspecific transporter from rat (rOCT1) that is expressed in renal proximal tubules and hepatocytes and… Expand
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Highly Cited
1997
Highly Cited
1997
Polyspecific organic cation transporters in the liver mediate the elimination of a wide array of endogenous amines and… Expand
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