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Soluble ErbB-1

Known as: sEGFR, sErbB-1, EGFR-ECD 
Soluble epidermal growth factor receptor is encoded by the human EGFR gene. This protein may be involved in the regulation of epidermal growth factor… 
National Institutes of Health

Related topics

Related topics

23 relations
Cell Differentiation processCell Growth RegulationCell ProliferationCell-Cell Adhesion Process

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
A novel discriminant score based on tumor-associated trypsin inhibitor for accurate diagnosis of metastasis in patients with breast cancer
Invasion and metastasis of solid tumors require proteolytic enzymes for degradation of the basal membrane and extracellular… 
2009
2009
A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo
A number of therapeutic strategies including small molecule tyrosine kinase inhibitors and monoclonal antibodies have been… 
2006
2006
Neutrophil elastase-initiated EGFR/MEK/ERK signaling counteracts stabilizing effect of autocrine TGF-beta on tropoelastin mRNA in lung fibroblasts.
Neutrophil elastase (NE) plays an important role in emphysema, a pulmonary disease associated with excessive elastolysis and… 
2005
2005
Serum soluble epidermal growth factor receptor concentrations decrease in postmenopausal metastatic breast cancer patients treated with letrozole.
Previous studies have implicated estrogen as a regulator of epidermal growth factor receptor (EGFR) expression in breast tumors… 
Highly Cited
2000
Highly Cited
2000
Real-time kinetic studies on the interaction of transforming growth factor alpha with the epidermal growth factor receptor extracellular domain reveal a conformational change model.
Transforming growth factor alpha (TGF-alpha), epidermal growth factor (EGF), and related factors mediate their biological effects… 
Highly Cited
2000
Highly Cited
2000
Stoichiometry, Kinetic and Binding Analysis of the Interaction between Epidermal Growth Factor (EGF) and the Extracellular Domain of the EGF Receptor
Abstract The kinetics, binding equilibria and stoichiometry of the interaction between epidermal growth factor and the soluble… 
Highly Cited
1998
Highly Cited
1998
Disulfide Bond Structure of Human Epidermal Growth Factor Receptor*
The extracellular domain of the human epidermal growth factor receptor (sEGFR) consists of 621 amino acid residues, including 50… 
Highly Cited
1997
Highly Cited
1997
Ligand-binding enhances the affinity of dimerization of the extracellular domain of the epidermal growth factor receptor.
We studied the dimerization of the recombinant soluble extracellular domain of the epidermal growth factor receptor (sEGFR) in… 
1994
1994
Protein microheterogeneity and crystal habits: the case of epidermal growth factor receptor isoforms as isolated in a multicompartment electrolyzer with isoelectric membranes.
1993
1993
Inhibition of epidermal growth factor receptor aggregation by an antibody directed against the epidermal growth factor receptor extracellular domain.
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