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Soluble ErbB-1

Known as: sEGFR, sErbB-1, EGFR-ECD 
Soluble epidermal growth factor receptor is encoded by the human EGFR gene. This protein may be involved in the regulation of epidermal growth factor… Expand
National Institutes of Health

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Highly Cited
2011
Highly Cited
2011
AIMS Members of the epidermal growth factor receptor (EGFR) family represent validated targets for anti-cancer therapy and EGFR… Expand
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Highly Cited
2009
Highly Cited
2009
This trial was conducted to assess the efficacy and safety of sorafenib in patients with metastatic breast cancer. In this… Expand
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Highly Cited
2008
Highly Cited
2008
In this study, we show that liquid chromatography coupled with tandem mass spectrometry provides a sensitive, specific, and… Expand
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Highly Cited
2007
Highly Cited
2007
Crystallographic studies showed that epidermal growth factor (EGF) receptor activation involves major domain rearrangements… Expand
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Highly Cited
2005
Highly Cited
2005
Recent structural studies of epidermal growth factor receptor (EGFR) family extracellular regions have identified an unexpected… Expand
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Highly Cited
2003
Highly Cited
2003
Epidermal growth factor (EGF) receptor is the prototype of the ErbB (HER) family receptor tyrosine kinases (RTKs), which regulate… Expand
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Highly Cited
2003
Highly Cited
2003
During inflammatory skin disorders such as psoriasis, atopic dermatitis, and allergic contact dermatitis, epidermal keratinocytes… Expand
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Highly Cited
2002
Highly Cited
2002
We report the crystal structure, at 2.5 A resolution, of a truncated human EGFR ectodomain bound to TGFalpha. TGFalpha interacts… Expand
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Highly Cited
1998
Highly Cited
1998
The extracellular domain of the human epidermal growth factor receptor (sEGFR) consists of 621 amino acid residues, including 50… Expand
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Highly Cited
1997
Highly Cited
1997
Receptor dimerization is generally considered to be the primary signaling event upon binding of a growth factor to its receptor… Expand
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