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Sodium-Glucose Transporter 2

Known as: SGLT2 Protein, SLC5A2 Protein, Sodium-Glucose Transporter 2 [Chemical/Ingredient] 
A sodium-glucose transporter that is expressed in the luminal membrane of the PROXIMAL KIDNEY TUBULES.
National Institutes of Health

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In BloodProcess of secretionSLC5A2 geneagonists

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SLC5A2 protein, human

Papers overview

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2020
2020
Dapagliflozin does not directly affect human α or β cells.
Selective inhibitors of sodium glucose cotransporter-2 (SGLT2) are widely used for the treatment of type 2 diabetes (T2D) and act… 
Review
2018
Review
2018
New Therapeutic Strategies for Type 2 Diabetes CME.
Pharmacological options for treatment of type 2 diabetes (T2D) have advanced rapidly during the last 10 years, allowing… 
Review
2017
Review
2017
Design and Solubility Enhancement of Empagliflozin Immediate Release Tablets by Using Solid Dispersion Method
To review available studies of Empagliflozin, a sodium glucose co-transporter-2 (SGLT2) inhibitor approved in 2014 by the… 
2015
2015
Sodium glucose transporter 2 inhibition, euglycemic ketosis and bone mineral loss: Refining clinical practices
Sir, The authors read with the great interest about the recent publication by Kalra et al. highlighting the occurrence of ketosis… 
2015
2015
In vitro characterization of luseogliflozin, a potent and competitive sodium glucose co-transporter 2 inhibitor: Inhibition kinetics and binding studies.
2014
2014
Sodium glucose transporter 2 (sglt2) inhibitors: Current status in clinical practice.
  • D. DuttaS. Kalra
  • JPMA. The Journal of the Pakistan Medical…
  • 2014
  • Corpus ID: 13519499
Sodium glucose transporter 2 (SGLT2) inhibitors including dapagliflozin, canagliflozin and empagliflozin act by a novel insulin… 
Review
2014
Review
2014
Blood pressure effects of glucagon-like peptide 1 analogues and sodium glucose transporter 2 inhibitors
Purpose of reviewThe growing number of obese patients with a high risk of developing hypertension and type 2 diabetes mellitus… 
2013
2013
Proximal tubule specific knockout of the Na+/H+ exchanger NHE3: effects on bicarbonate absorption and ammonium excretion
The existing NHE3 knockout mouse has significant intestinal electrolyte absorption defects, making this model unsuitable for the… 
Review
2010
Review
2010
Exploring newer target sodium glucose transporter 2 for the treatment of diabetes mellitus.
Diabetes mellitus is an independent risk factor for the development of coronary artery disease, myocardial infarction… 
2005
2005
ATP stimulates Na+-glucose cotransporter activity via cAMP and p38 MAPK in renal proximal tubule cells.
Extracellular ATP plays an important role in the regulation of renal function. However, the effect of ATP on the Na(+)-glucose… 
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