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Small T-Antigen

Known as: Small T Antigen, T Antigen, Small, T-Antigen, Small 
National Institutes of Health

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Viral Tumor Antigens

Papers overview

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2008
2008
Cyclin E and SV40 Small t Antigen Cooperate to Bypass Quiescence and Contribute to Transformation by Activating CDK2 in Human Fibroblasts*
Cyclin E overexpression is observed in multiple human tumors and linked to poor prognosis. We have previously shown that ectopic… 
2008
2008
Clonal selection in malignant transformation of human fibroblasts transduced with defined cellular oncogenes.
Recent evidence has implied that disruption of a limited number of defined cellular pathways is necessary and sufficient for… 
2004
2004
Identification of TAZ as a Binding Partner of the Polyomavirus T Antigens
ABSTRACT A polyomavirus mutant isolated by the tumor host range selection procedure (19) has a three-amino-acid deletion (Δ2-4… 
2001
2001
Induction of p53-Independent Apoptosis by Simian Virus 40 Small t Antigen
ABSTRACT Simian virus 40 small t antigen (st) is required for optimal transformation and replication properties of the virus. We… 
2001
2001
Polyomavirus Small t Antigen Prevents Retinoic Acid-Induced Retinoblastoma Protein Hypophosphorylation and Redirects Retinoic Acid-Induced G0 Arrest and Differentiation to Apoptosis
ABSTRACT Polyomavirus small t antigen (ST) impedes late features of retinoic acid (RA)-induced HL-60 myeloid differentiation as… 
2001
2001
JC virus large T protein transforms rodent cells but is not involved in human medulloblastoma
JC virus (JCV) together with Simian virus 40 (SV40) and BK virus (BKV), belong to the polyomavirus group and these viruses are… 
1998
1998
Signaling from Polyomavirus Middle T and Small T Defines Different Roles for Protein Phosphatase 2A
ABSTRACT Polyomavirus causes a broad spectrum of tumors as the result of the action of its early proteins. This work compares… 
1996
1996
Simian virus 40 small t antigen activates the carboxyl-terminal transforming p53-binding domain of large T antigen
Expression of the simian virus 40 large T antigen (large T) in F111 rat fibroblasts generated only minimal transformants (e.g… 
1992
1992
Involvement of simian virus 40 (SV40) small t antigen in trans activation of SV40 early and late promoters
We have previously found that simian virus 40 (SV40) small t antigen (small t) can trans activate the E2A and VA-I genes of… 
1991
1991
The polyomavirus early region gene in transgenic mice causes vascular and bone tumors
Transgenic mice carrying the entire polyomavirus (Py) early region consistently develop both vascular and bone tumors. This tumor… 
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