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Altered peptidase and viral-specific T cell response in LMP2 mutant mice.
MHC class I molecules present peptides generated by processing of endogenously synthesized proteins to CD8+ T lymphocytes. Recently, large proteolytic complexes, termed proteasomes, were implicatedExpand
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Chk2‐deficient mice exhibit radioresistance and defective p53‐mediated transcription
The mammalian Chk2 kinase is thought to mediate ATM‐dependent signaling in response to DNA damage. The physiological role of mammalian Chk2 has now been investigated by the generation ofExpand
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Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I.
Infertility is a common feature of the human disorder ataxia-telangiectasia and Atm-deficient mice are completely infertile. To gain further insight into the role of ATM in meiosis, we examinedExpand
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Pertussis toxin-sensitive signal controls the trafficking of thymocytes across the corticomedullary junction in the thymus.
We investigated a role of chemokines in thymocyte trafficking. Genes encoding stromal cell-derived factor-1 and its receptor CXCR4 were detected in the cortex by in situ hybridization. EarlyExpand
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The Distribution of Inflammation and Virus in Human Enterovirus 71 Encephalomyelitis Suggests Possible Viral Spread by Neural Pathways
Previous neuropathologic studies of Enterovirus 71 encephalomyelitis have not investigated the anatomic distribution of inflammation and viral localization in the central nervous system (CNS) inExpand
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Hydrocephalus, Situs Inversus, Chronic Sinusitis, and Male Infertility in DNA Polymerase λ-Deficient Mice: Possible Implication for the Pathogenesis of Immotile Cilia Syndrome
ABSTRACT A growing number of DNA polymerases have been identified, although their physiological function and relation to human disease remain mostly unknown. DNA polymerase λ (Pol λ; also known asExpand
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HIV‐Associated Disease of the Nervous System: Review of Nomenclature and Proposal for Neuropathology‐Based Terminology
Herbert Budka 1, Clayton A. Wiley 2, Paul Kleihues 3, Juan Artigas 4, Arthur K. Asbury 5, Eun-Sook Cho 6, David R. Cornblath 7, Mauro C. Dal Canto 8, Umberto DeGirolami 9, Dennis Dickson 10, Leon G.Expand
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P‐ANCA‐positive Wegener’s granulomatosis presenting with hypertrophic pachymeningitis and multiple cranial neuropathies: Case report and review of literature
An autopsy case of hypertrophic pachymeningitis and multiple cranial neuropathies is reported. A 53‐year‐old woman with paraplegia and various neurological signs which developed over a 2 year periodExpand
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The agnoprotein of polyomaviruses: A multifunctional auxiliary protein
The late region of the three primate polyomaviruses (JCV, BKV, and SV40) encodes a small, highly basic protein known as agnoprotein. While much attention during the last two decades has focused onExpand
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The Human Polyoma JC Virus Agnoprotein Acts as a Viroporin
Virus infections can result in a range of cellular injuries and commonly this involves both the plasma and intracellular membranes, resulting in enhanced permeability. Viroporins are a group ofExpand
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