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Single-Domain Antibodies

Known as: Antibodies, Single-Domain, Single Domain Antibodies, Single-Domain Antibodies [Chemical/Ingredient] 
An immunoglobulin fragment composed of one variable domain from an IMMUNOGLOBULIN HEAVY CHAIN or IMMUNOGLOBULIN LIGHT CHAIN.
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (8)

99m Tc-D10 nonobodyALX-0061DMS5540Immunoglobulin VH Domain Fragments
In BloodSingle-Chain Antibodiesaspects of radiation effectsphysiological aspects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Evaluating a Single Domain Antibody Targeting Human PD-L1 as a Nuclear Imaging and Therapeutic Agent
The PD-1:PD-L1 immune checkpoint axis is central in the escape of cancer cells from anticancer immune responses. Monoclonal… 
2019
2019
Oriented Immobilization of Single-Domain Antibodies Using SpyTag/SpyCatcher Yields Improved Limits of Detection.
Single-domain antibodies (sdAb), recombinantly produced variable heavy domains derived from the unconventional heavy chain… 
Review
2019
Review
2019
Structure and development of single domain antibodies as modules for therapeutics and diagnostics
Since their discovery just over 25 years ago, the single variable domain from heavy-chain-only antibodies plays a role in an… 
Highly Cited
2012
Highly Cited
2012
Isolation of alpaca anti-hapten heavy chain single domain antibodies for development of sensitive immunoassay.
Some unique subclasses of Camelidae antibodies are devoid of the light chain, and the antigen binding site is comprised… 
Highly Cited
2009
Highly Cited
2009
Transient expression and purification of chimeric heavy chain antibodies.
Highly Cited
2007
Highly Cited
2007
Single domain antibodies from llama effectively and specifically block T cell ecto‐ADP‐ribosyltransferase ART2.2 in vivo
The purpose of our study was to develop a tool for blocking the function of a specific leukocyte ecto‐enzyme in vivo. ART2.2 is a… 
Highly Cited
2007
Highly Cited
2007
Selection of Genetically Encoded Fluorescent Single Domain Antibodies Engineered for Efficient Expression in Escherichia coli*
Genetically encoded fluorescent antibodies are desirable for many applications in biotechnology and proteomics. However, the… 
Highly Cited
2006
Highly Cited
2006
Facile generation of heat-stable antiviral and antitoxin single domain antibodies from a semisynthetic llama library.
Llamas possess a class of unconventional immunoglobulins that have only heavy chains; unpaired heavy variable domains are… 
Review
2005
Review
2005
Intrabody applications in neurological disorders: progress and future prospects.
Highly Cited
2003
Highly Cited
2003
Isolation and characterization of an IgNAR variable domain specific for the human mitochondrial translocase receptor Tom70.
The new antigen receptor (IgNAR) from sharks is a disulphide bonded dimer of two protein chains, each containing one variable and… 
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