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Silent Mutation

Known as: Exonic Synonymous Mutation, Exon Synonymous Mutation, Codon Substitution, Synonymous 
A point mutation occurring within the protein-coding region of a gene, and which codes for the same amino acid as expected.
National Institutes of Health

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aspects of radiation effectsphysiological aspects

Papers overview

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Highly Cited
2007
Highly Cited
2007
How do synonymous mutations affect fitness?
While it has often been assumed that, in humans, synonymous mutations would have no effect on fitness, let alone cause disease… 
Highly Cited
2007
Highly Cited
2007
Low MHC variation in the endangered Galápagos penguin (Spheniscus mendiculus)
The major histocompatibility complex (MHC) is one of the most polymorphic regions of the genome, likely due to balancing… 
Review
2004
Review
2004
Mutation and selection at silent and replacement sites in the evolution of animal mitochondrial DNA
Two patterns are presented that illustrate the interaction of mutation and selection in the evolution of animal mtDNA: 1… 
Highly Cited
1997
Highly Cited
1997
Synonymous substitution rates in Drosophila: Mitochondrial versus nuclear genes
Synonymous substitution rates in mitochondrial and nuclear genes of Drosophila were compared. To make accurate comparisons, we… 
Highly Cited
1996
Highly Cited
1996
FGFR2 exon IIIa and IIIc mutations in Crouzon, Jackson-Weiss, and Pfeiffer syndromes: evidence for missense changes, insertions, and a deletion due to alternative RNA splicing.
Fibroblast growth factor receptor 2 (FGFR2) mutations have been associated with the craniosynostotic conditions Crouzon, Jackson… 
Highly Cited
1992
Highly Cited
1992
Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population.
The aims of this study were to detect polymorphic sites in the apolipoprotein (apo) A-IV gene, to establish their frequencies, to… 
Highly Cited
1986
Highly Cited
1986
Isolation and characterization of sarcomeric actin genes expressed in Xenopus laevis embryos.
Highly Cited
1986
Highly Cited
1986
A simple and efficient procedure for saturation mutagenesis using mixed oligodeoxynucleotides.
Highly Cited
1986
Highly Cited
1986
The rate with which spontaneous mutation alters the electrophoretic mobility of polypeptides.
Studies of a Japanese population, involving a total of 539,170 locus tests distributed over 36 polypeptides, yielded three… 
Highly Cited
1979
Highly Cited
1979
The ovalbumin gene: Alleles created by mutations in the intervening sequences of the natural gene
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