Silent Mutation

Known as: Exonic Synonymous Mutation, Exon Synonymous Mutation, Codon Substitution, Synonymous 
A point mutation occurring within the protein-coding region of a gene, and which codes for the same amino acid as expected.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2018
05101519942018

Papers overview

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2016
2016
We analyze de novo synonymous mutations identified in autism spectrum disorders (ASDs) and schizophrenia (SCZ) with potential… (More)
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2016
2016
Contrary to previous understanding, recent evidence indicates that synonymous codon changes may sometimes face strong selection… (More)
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Highly Cited
2014
Highly Cited
2014
Synonymous mutations change the sequence of a gene without directly altering the sequence of the encoded protein. Here, we… (More)
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2014
2014
Synonymous mutations do not alter amino acids and are generally considered nonfunctional in cancer. Supek et al. now present a… (More)
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2013
2013
Analyses of somatic hypermutation (SHM) patterns in B cell immunoglobulin (Ig) sequences contribute to our basic understanding of… (More)
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2013
2013
Aicardi-Goutières syndrome is an inflammatory disorder resulting from mutations in TREX1, RNASEH2A/2B/2C, SAMHD1, or ADAR1. Here… (More)
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2013
2013
Biased codon usage in protein-coding genes is pervasive, whereby amino acids are largely encoded by a specific subset of possible… (More)
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2012
2012
Gene translation is a central process in all living organism with important ramifications to almost every biomedical field… (More)
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2006
2006
One method for diagnosing the mode of sequence evolution considers the ratio of nonsynonymous substitutions per nonsynonymous… (More)
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1994
1994
ABSTRACT: Pyruvate dehydrogenase (PDH)-Elα deficiency has recently been studied at the molecular-genetic level. The gene is… (More)
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