• Publications
  • Influence
The Genetic Code Is One in a Million
Abstract. Statistical and biochemical studies of the genetic code have found evidence of nonrandom patterns in the distribution of codon assignments. It has, for example, been shown that the codeExpand
  • 419
  • 45
  • Open Access
Hearing silence: non-neutral evolution at synonymous sites in mammals
Although the assumption of the neutral theory of molecular evolution — that some classes of mutation have too small an effect on fitness to be affected by natural selection — seems intuitivelyExpand
  • 729
  • 38
Clustering of housekeeping genes provides a unified model of gene order in the human genome
It is often supposed that, except for tandem duplicates, genes are randomly distributed throughout the human genome. However, recent analyses suggest that when all the genes expressed in a givenExpand
  • 541
  • 32
Mitochondria and male disease
  • 266
  • 25
  • Open Access
A Predictive Model for Delirium in Hospitalized Elderly Medical Patients Based on Admission Characteristics
Delirium, defined as an acute disorder of attention and cognition, occurs in 14% to 56% of elderly, hospitalized patients [1-16] and may be the most frequent complication of hospitalization in thisExpand
  • 751
  • 24
Positively Charged Residues Are the Major Determinants of Ribosomal Velocity
Positively charged amino acid residues in the nascent peptide, not RNA-level features as long thought, slow ribosomes.
  • 196
  • 20
  • Open Access
Early fixation of an optimal genetic code.
The evolutionary forces that produced the canonical genetic code before the last universal ancestor remain obscure. One hypothesis is that the arrangement of amino acid/codon assignments results fromExpand
  • 231
  • 17
  • Open Access
A Quantitative Measure of Error Minimization in the Genetic Code
We have calculated the average effect of changing a codon by a single base for all possible single-base changes in the genetic code and for changes in the first, second, and third codon positionsExpand
  • 117
  • 17
Comparisons of dN/dS are time dependent for closely related bacterial genomes.
The ratio of non-synonymous (dN) to synonymous (dS) changes between taxa is frequently computed to assay the strength and direction of selection. Here we note that for comparisons between closelyExpand
  • 351
  • 15
  • Open Access
Environmentally responsive genome-wide accumulation of de novo Arabidopsis thaliana mutations and epimutations.
Evolution is fueled by phenotypic diversity, which is in turn due to underlying heritable genetic (and potentially epigenetic) variation. While environmental factors are well known to influence theExpand
  • 110
  • 15
  • Open Access