Sickle Hemoglobin

Known as: haemoglobin s, Hemoglobin, Sickle [Chemical/Ingredient], hemoglobins s 
An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
It has been 100 years since the first report of sickle haemoglobin (HbS). More than 50 years ago, it was suggested that the gene… (More)
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Highly Cited
2008
Highly Cited
2008
Sickle trait, the heterozygous state of normal hemoglobin A (HbA) and sickle hemoglobin S (HbS), confers protection against… (More)
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Highly Cited
2003
Highly Cited
2003
Fetal hemoglobin (HbF) decreases polymerization of sickle hemoglobin (HbS) and improves outcomes in sickle cell disease (SSD… (More)
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Highly Cited
2002
Highly Cited
2002
Vascular occlusion is the major cause of morbidity and mortality in sickle cell disease but its mechanisms are poorly understood… (More)
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Highly Cited
2001
Highly Cited
2001
This paper examines the joint time series of the S&P 500 index and near-the-money short-dated option prices with an arbitrage… (More)
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Highly Cited
1998
Highly Cited
1998
Permission is granted to copy, distribute and/or modify this document under the terms of the Open Publication License, version 2… (More)
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Highly Cited
1997
Highly Cited
1997
To create mice expressing exclusively human sickle hemoglobin (HbS), transgenic mice expressing human alpha-, gamma-, and betaS… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND Information on life expectancy and risk factors for early death among patients with sickle cell disease (sickle cell… (More)
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Highly Cited
1988
Highly Cited
1988
The pleiotropic effect of the sickle gene suggests that factors in addition to polymerization of the mutant gene product might be… (More)
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Highly Cited
1985
Highly Cited
1985
A double nucleation mechanism for the polymerization of sickle hemoglobin is described. The mechanism accounts for all of the… (More)
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