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Serine Palmitoyltransferase 1, Human
Known as:
LCB 1
, SPT 1
, Long Chain Base Biosynthesis Protein 1
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Serine palmitoyltransferase 1 (473 aa, ~53 kDa) is encoded by the human SPTLC1 gene. This protein plays a role in the biosynthesis of sphingolipids.
National Institutes of Health
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Related topics
Related topics
9 relations
Enzyme Gene
Integral Membrane Proteins
Lipid Metabolism
SPTLC1 gene
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Broader (1)
serine palmitoyltransferase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Sphingolipids metabolism in the salivary glands of rats with obesity and streptozotocin induced diabetes
Marta Garbowska
,
B. Łukaszuk
,
+6 authors
A. Zalewska
Journal of cellular physiology
2017
Corpus ID: 2017344
Diabetes is considered a major public health problem affecting millions of individuals worldwide. Remarkably, scientific reports…
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2014
2014
EFFECT OF DELAYED EMERGENCE ON CORN (ZEA MAYS L.) GRAIN YIELD
E. Rutto
,
Cody Daft
,
+4 authors
W. Raun
2014
Corpus ID: 62819366
Uneven crop stands result in a reduction in corn yield production. This study was conducted to determine the effect of delayed…
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2010
2010
Magnesium deficiency upregulates serine palmitoyl transferase (SPT 1 and SPT 2) in cardiovascular tissues: relationship to serum ionized Mg and cytochrome c.
B. Altura
,
N. Shah
,
Zhiqiang Li
,
Xian-cheng Jiang
,
José Luis Perez-Albela
,
B. T. Altura
American journal of physiology. Heart and…
2010
Corpus ID: 7563250
The present work tested the hypothesis that a short-term dietary deficiency of magnesium (Mg) (21 days) in rats would result in…
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Highly Cited
2006
Highly Cited
2006
Metformin influences cardiomyocyte cell death by pathways that are dependent and independent of caspase-3
D. An
,
G. Kewalramani
,
+6 authors
B. Rodrigues
Diabetologia
2006
Corpus ID: 24945397
Aims/hypothesisMetformin has been shown to increase fatty acid oxidation, an effect mediated by AMP activated protein kinase…
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2006
2006
A concise synthesis of tetrahydroxy-LCB, alpha-galactosyl ceramide, and 1,4-dideoxy-1,4-imino-L-ribitol via D-allosamines as key building blocks.
Shun-Yuan Luo
,
Suvarn S. Kulkarni
,
Chien-Hung Chou
,
Wei Liao
,
S. Hung
The Journal of organic chemistry
2006
Corpus ID: 23332005
The total syntheses of tetrahydroxy-LCB 1, alpha-galactosyl ceramide 2, and 1,4-dideoxy-1,4-imino-L-ribitol 3 via D-allosamine…
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Highly Cited
1994
Highly Cited
1994
The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis.
M. Nagiec
,
J. Baltisberger
,
G. B. Wells
,
R. Lester
,
R. C. Dickson
Proceedings of the National Academy of Sciences…
1994
Corpus ID: 43786885
The first and committed step in synthesis of the ceramide moiety of sphingolipids is catalyzed by serine palmitoyltransferase (EC…
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Highly Cited
1988
Highly Cited
1988
Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway.
A. Merrill
,
E. Wang
,
R. Mullins
Biochemistry
1988
Corpus ID: 10673522
Serine palmitoyltransferase (EC 2.3.1.50) catalyzes the condensation of L-serine and palmitoyl-CoA to yield 3-ketosphinganine in…
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