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Serine Palmitoyltransferase 1, Human

Known as: LCB 1, SPT 1, Long Chain Base Biosynthesis Protein 1 
Serine palmitoyltransferase 1 (473 aa, ~53 kDa) is encoded by the human SPTLC1 gene. This protein plays a role in the biosynthesis of sphingolipids.
National Institutes of Health

Related topics

Related topics

9 relations
Enzyme GeneIntegral Membrane ProteinsLipid MetabolismSPTLC1 gene

Broader (1)

serine palmitoyltransferase

Papers overview

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2017
2017
Sphingolipids metabolism in the salivary glands of rats with obesity and streptozotocin induced diabetes
Diabetes is considered a major public health problem affecting millions of individuals worldwide. Remarkably, scientific reports… 
2014
2014
EFFECT OF DELAYED EMERGENCE ON CORN (ZEA MAYS L.) GRAIN YIELD
Uneven crop stands result in a reduction in corn yield production. This study was conducted to determine the effect of delayed… 
2010
2010
Magnesium deficiency upregulates serine palmitoyl transferase (SPT 1 and SPT 2) in cardiovascular tissues: relationship to serum ionized Mg and cytochrome c.
The present work tested the hypothesis that a short-term dietary deficiency of magnesium (Mg) (21 days) in rats would result in… 
Highly Cited
2006
Highly Cited
2006
Metformin influences cardiomyocyte cell death by pathways that are dependent and independent of caspase-3
Aims/hypothesisMetformin has been shown to increase fatty acid oxidation, an effect mediated by AMP activated protein kinase… 
2006
2006
A concise synthesis of tetrahydroxy-LCB, alpha-galactosyl ceramide, and 1,4-dideoxy-1,4-imino-L-ribitol via D-allosamines as key building blocks.
The total syntheses of tetrahydroxy-LCB 1, alpha-galactosyl ceramide 2, and 1,4-dideoxy-1,4-imino-L-ribitol 3 via D-allosamine… 
Highly Cited
1994
Highly Cited
1994
The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis.
The first and committed step in synthesis of the ceramide moiety of sphingolipids is catalyzed by serine palmitoyltransferase (EC… 
Highly Cited
1988
Highly Cited
1988
Kinetics of long-chain (sphingoid) base biosynthesis in intact LM cells: effects of varying the extracellular concentrations of serine and fatty acid precursors of this pathway.
Serine palmitoyltransferase (EC 2.3.1.50) catalyzes the condensation of L-serine and palmitoyl-CoA to yield 3-ketosphinganine in… 
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