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serine palmitoyltransferase

Known as: Palmitoyltransferase, Serine, Palmitoyl-Coenzyme A-L-Serine C-Palmitoyltransferase (Decarboxylating), Serine C Palmitoyltransferase 
A key enzyme in SPHINGOLIPIDS biosynthesis, this enzyme catalyzes the pyridoxal-5'-phosphate-dependent condensation of L-SERINE and PALMITOYL… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Sphingolipids comprise a diverse family of lipids that perform multiple functions in both structure of cellular membranes and… Expand
Highly Cited
2011
Highly Cited
2011
The contribution of mutations in amyloid precursor protein (APP) and presenilin (PSEN) to familial Alzheimer's disease (AD) is… Expand
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Highly Cited
2009
Highly Cited
2009
Serine palmitoyltransferase (SPT) catalyzes the first committed step in sphingolipid biosynthesis. In yeast, SPT is composed of a… Expand
Highly Cited
2007
Highly Cited
2007
Sphingolipid biosynthesis commences with the condensation of L-serine and palmitoyl-CoA to produce 3-ketodihydrosphingosine (KDS… Expand
Review
2003
Review
2003
  • K. Hanada
  • Biochimica et biophysica acta
  • 2003
  • Corpus ID: 23146294
The first step in the biosynthesis of sphingolipids is the condensation of serine and palmitoyl CoA, a reaction catalyzed by… Expand
Highly Cited
2001
Highly Cited
2001
Hereditary sensory neuropathy type I (HSN1) is the most common hereditary disorder of peripheral sensory neurons. HSN1 is an… Expand
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Highly Cited
2000
Highly Cited
2000
The de novo pathway of sphingolipid synthesis has been identified recently as a novel means of generating ceramide during… Expand
Highly Cited
1998
Highly Cited
1998
We reported that the lipoapoptosis of beta-cells observed in fat-laden islets of obese fa/fa Zucker Diabetic Fatty (ZDF) rats… Expand
Highly Cited
1995
Highly Cited
1995
ISP-1/myriocin is a new type of remarkably potent immunosuppressant, the structure of which is homologous to sphingosine. ISP-1… Expand
Highly Cited
1992
Highly Cited
1992
Serine palmitoyltransferase, 3-dehydrosphinganine reductase and sphinganine N-acyltransferase are responsible for the first steps… Expand