SPTLC1 gene

Known as: Serine Palmitoyltransferase, Long Chain Base Subunit 1 Gene, SPTLC1, LCB1 
This gene plays a role in lipid modification.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1974-2017
024619742017

Papers overview

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2009
2009
Hereditary sensory and autonomic neuropathies (HSAN) are clinically and genetically heterogeneous disorders characterized by… (More)
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Highly Cited
2006
Highly Cited
2006
Serine palmitoyltransferase (SPT) catalyzes the first step of sphingolipid biosynthesis. In yeast and mammalian cells, SPT is a… (More)
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2005
2005
Mutations in enzymes involved in sphingolipid metabolism and trafficking cause a variety of neurological disorders, but details… (More)
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Highly Cited
2001
Highly Cited
2001
Hereditary sensory neuropathy type 1 (HSN1, MIM 162400; ref. 1) genetically maps to human chromosome 9q22 (refs. 2–4). We report… (More)
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Highly Cited
2001
Highly Cited
2001
Hereditary sensory neuropathy type I (HSN1) is the most common hereditary disorder of peripheral sensory neurons. HSN1 is an… (More)
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2000
2000
Imbalance between cardiac oxygen supply and demand may trigger cardiac events in already vulnerable hemodialysis (HD) patients… (More)
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1998
Highly Cited
1998
Lysenin, a hemolytic protein derived from the earthworm Eisenia foetida, has a high affinity for sphingomyelin. Chinese hamster… (More)
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Highly Cited
1997
Highly Cited
1997
Serine palmitoyltransferase (SPT, EC 2.3.1.50) is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5… (More)
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1997
1997
Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the initial step dedicated to sphingolipid biosynthesis and is thought… (More)
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1991
1991
The existence of auxotrophic mutants of Saccharomyces cerevisiae having an absolute requirement for the long-chain base (lcb… (More)
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