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Serine/Threonine-Protein Phosphatase 2A 65 kDa Regulatory Subunit A Alpha Isoform

Known as: PP2A Subunit A Isoform R1-Alpha, Medium Tumor Antigen-Associated 61 kDa Protein, PPP2R1A 
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (589 aa, ~65 kDa) is encoded by the human PPP2R1A gene. This… 
National Institutes of Health

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10 relations
ApoptosisCanonical Wnt Signaling PathwayCell Proliferation Regulatory ProcessCentromere

Papers overview

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2020
2020
Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1
Protein phosphatase 2A (PP2A) critically regulates cell signaling and is a human tumor suppressor. PP2A complexes are modulated… 
Highly Cited
2016
Highly Cited
2016
Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth.
Somatic missense mutations in the Ser/Thr protein phosphatase 2A (PP2A) Aα scaffold subunit gene PPP2R1A are among the few… 
Highly Cited
2015
Highly Cited
2015
Comprehensive assessment of cancer missense mutation clustering in protein structures
Significance Tumor sequencing efforts have enabled the identification of cancer genes based on an excess of mutations in the gene… 
2014
2014
Synthetic genetic array screen identifies PP2A as a therapeutic target in Mad2-overexpressing tumors
Significance The spindle checkpoint is required for proper chromosome segregation. Mitotic arrest deficiency 2 (Mad2), a… 
2013
2013
PPP2R2C Loss Promotes Castration-Resistance and Is Associated with Increased Prostate Cancer-Specific Mortality
Metastatic prostate cancers generally rely on androgen receptor (AR) signaling for growth and survival, even following systemic… 
Highly Cited
2012
Highly Cited
2012
PPP2R1A mutations are common in the serous type of endometrial cancer
Recently unbiased sequencing efforts identified PPP2R1A mutations in clear cell ovarian cancers (OCC). Similar mutations were… 
Highly Cited
2011
Highly Cited
2011
Dephosphorylation of Carma1 by PP2A negatively regulates T‐cell activation
The Carma1–Bcl10–Malt1 (CBM) complex bridges T‐cell receptor (TCR) signalling to the canonical IκB kinase (IKK)/NF‐κB pathway. NF… 
Highly Cited
2009
Highly Cited
2009
Two types of human malignant melanoma cell lines revealed by expression patterns of mitochondrial and survival-apoptosis genes: implications for malignant melanoma therapy
Human malignant melanoma has poor prognosis because of resistance to apoptosis and therapy. We describe identification of the… 
Highly Cited
2000
Highly Cited
2000
Low frequency of alterations of the α (PPP2R1A) and β (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms
The phosphatase 2A (PP2A) is one of the major cellular serine-threonine phosphatases. It was recently shown that the gene… 
Highly Cited
2000
Highly Cited
2000
Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms.
The phosphatase 2A (PP2A) is one of the major cellular serine-threonine phosphatases. It was recently shown that the gene… 
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