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Sentrin-Specific Protease 1

Known as: Sentrin/SUMO-Specific Protease SENP1 
Sentrin-specific protease 1 (644 aa, ~73 kDa) is encoded by the human SENP1 gene. This protein is involved in both caspase activation and protein… Expand
National Institutes of Health

Related topics

Related topics

16 relations
Androgen Receptor Regulation PathwayCaspase ActivationCaspase-Dependent ApoptosisCell Nucleus
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Broader (1)

Cysteine Endopeptidases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
SUMO protease SENP1 deSUMOylates and stabilizes c-Myc
Significance c-Myc is dynamically regulated by posttranslational modifications, including SUMOylation. However, how SUMOylation… Expand
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2018
2018
MicroRNA-186 Suppresses Cell Proliferation and Metastasis Through Targeting Sentrin-Specific Protease 1 in Renal Cell Carcinoma.
Recent evidence suggests that dysregulation of microRNAs is associated with the development of multiple malignancies. miR-186 has… Expand
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2017
2017
11&bgr;-HSD2 SUMOylation Modulates Cortisol-Induced Mineralocorticoid Receptor Nuclear Translocation Independently of Effects on Transactivation
The enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) has an essential role in aldosterone target tissues, conferring… Expand
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2017
2017
SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling
Rationale: The highly conserved NOTCH (neurogenic locus notch homolog protein) signaling pathway functions as a key cell–cell… Expand
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2016
2016
Activation of liver X receptor attenuates lysophosphatidylcholine‐induced IL‐8 expression in endothelial cells via the NF‐κB pathway and SUMOylation
The liver X receptor (LXR) is a cholesterol‐sensing nuclear receptor that has an established function in lipid metabolism… Expand
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2015
2015
The prognostic value of SUMO1/Sentrin specific peptidase 1 (SENP1) in prostate cancer is limited to ERG-fusion positive tumors lacking PTEN deletion
BackgroundPosttranscriptional protein modification by SUMOylation plays an important role in tumor development and progression… Expand
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2015
2015
SENP1 regulates hepatocyte growth factor-induced migration and epithelial-mesenchymal transition of hepatocellular carcinoma
The deregulation of HGF/c-Met signaling is implicated in epithelial-mesenchymal transition (EMT) and progress of hepatocellular… Expand
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Highly Cited
2012
Highly Cited
2012
Betulinic Acid Decreases Specificity Protein 1 (Sp1) Level via Increasing the Sumoylation of Sp1 to Inhibit Lung Cancer Growth
Previous studies have shown that the inhibitory effect of betulinic acid (BA) on specificity protein 1 (Sp1) expression is… Expand
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Highly Cited
2006
Highly Cited
2006
The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing.
The SUMO (small ubiquitin-like modifier)-specific protease SENP1 (sentrin-specific protease 1) can process the three forms of… Expand
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Highly Cited
2005
Highly Cited
2005
Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1.
SUMO (small ubiquitin-related modifier) is a member of the ubiquitin-like protein family that regulates cellular function of a… Expand
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