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Sentrin-Specific Protease 1

Known as: Sentrin/SUMO-Specific Protease SENP1 
Sentrin-specific protease 1 (644 aa, ~73 kDa) is encoded by the human SENP1 gene. This protein is involved in both caspase activation and protein… 
National Institutes of Health

Papers overview

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2018
2018
Significance c-Myc is dynamically regulated by posttranslational modifications, including SUMOylation. However, how SUMOylation… 
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2018
2018
Recent evidence suggests that dysregulation of microRNAs is associated with the development of multiple malignancies. miR-186 has… 
2017
2017
The enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) has an essential role in aldosterone target tissues, conferring… 
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2017
2017
Targeted therapies promise to increase the safety and efficacy of treatments against diseases ranging from cancer to viral… 
2016
2016
The liver X receptor (LXR) is a cholesterol‐sensing nuclear receptor that has an established function in lipid metabolism… 
2015
2015
BackgroundPosttranscriptional protein modification by SUMOylation plays an important role in tumor development and progression… 
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2015
2015
The deregulation of HGF/c-Met signaling is implicated in epithelial-mesenchymal transition (EMT) and progress of hepatocellular… 
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Highly Cited
2012
Highly Cited
2012
Previous studies have shown that the inhibitory effect of betulinic acid (BA) on specificity protein 1 (Sp1) expression is… 
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Highly Cited
2006
Highly Cited
2006
The SUMO (small ubiquitin-like modifier)-specific protease SENP1 (sentrin-specific protease 1) can process the three forms of… 
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Highly Cited
2005
Highly Cited
2005
SUMO (small ubiquitin-related modifier) is a member of the ubiquitin-like protein family that regulates cellular function of a… 
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