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Sentrin-Specific Protease 1
Known as:
Sentrin/SUMO-Specific Protease SENP1
Sentrin-specific protease 1 (644 aa, ~73 kDa) is encoded by the human SENP1 gene. This protein is involved in both caspase activation and protein…
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National Institutes of Health
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Related topics
Related topics
16 relations
Androgen Receptor Regulation Pathway
Caspase Activation
Caspase-Dependent Apoptosis
Cell Nucleus
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Broader (1)
Cysteine Endopeptidases
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
SUMO protease SENP1 deSUMOylates and stabilizes c-Myc
Xiao‐Xin Sun
,
Yingxiao Chen
,
+6 authors
M. Dai
Proceedings of the National Academy of Sciences
2018
Corpus ID: 52957236
Significance c-Myc is dynamically regulated by posttranslational modifications, including SUMOylation. However, how SUMOylation…
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2018
2018
MicroRNA-186 Suppresses Cell Proliferation and Metastasis Through Targeting Sentrin-Specific Protease 1 in Renal Cell Carcinoma.
D. Jiao
,
Man Wu
,
L. Ji
,
F. Liu
,
Yingying Liu
Oncology Research
2018
Corpus ID: 3720083
Recent evidence suggests that dysregulation of microRNAs is associated with the development of multiple malignancies. miR-186 has…
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2017
2017
11&bgr;-HSD2 SUMOylation Modulates Cortisol-Induced Mineralocorticoid Receptor Nuclear Translocation Independently of Effects on Transactivation
Rubén Jiménez-Canino
,
F. Lorenzo-Diaz
,
+5 authors
D. Álvarez de la Rosa
Endocrinology
2017
Corpus ID: 45448567
The enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) has an essential role in aldosterone target tissues, conferring…
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2017
2017
Modularly Constructed Synthetic Granzyme B Molecule Enables Interrogation of Intracellular Proteases for Targeted Cytotoxicity.
P. Ho
,
Christopher Ede
,
Y. Chen
ACS Synthetic Biology
2017
Corpus ID: 3834385
Targeted therapies promise to increase the safety and efficacy of treatments against diseases ranging from cancer to viral…
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2016
2016
SENP1, but not fetal hemoglobin, differentiates Andean highlanders with chronic mountain sickness from healthy individuals among Andean highlanders.
M. Hsieh
,
D. Callacondo
,
+8 authors
J. Tisdale
Experimental Hematology
2016
Corpus ID: 3534188
2016
2016
SENP1 regulates hepatocyte growth factor-induced migration and epithelial-mesenchymal transition of hepatocellular carcinoma
Wenwen Zhang
,
Huiyan Sun
,
+6 authors
Lisheng Wang
Tumor Biology
2016
Corpus ID: 16790934
The deregulation of HGF/c-Met signaling is implicated in epithelial-mesenchymal transition (EMT) and progress of hepatocellular…
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2015
2015
The prognostic value of SUMO1/Sentrin specific peptidase 1 (SENP1) in prostate cancer is limited to ERG-fusion positive tumors lacking PTEN deletion
C. Burdelski
,
Devi Menan
,
+13 authors
T. Krech
BMC Cancer
2015
Corpus ID: 8454098
BackgroundPosttranscriptional protein modification by SUMOylation plays an important role in tumor development and progression…
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Highly Cited
2012
Highly Cited
2012
Betulinic Acid Decreases Specificity Protein 1 (Sp1) Level via Increasing the Sumoylation of Sp1 to Inhibit Lung Cancer Growth
T. Hsu
,
Meijie Wang
,
+5 authors
J. Hung
Molecular Pharmacology
2012
Corpus ID: 7245614
Previous studies have shown that the inhibitory effect of betulinic acid (BA) on specificity protein 1 (Sp1) expression is…
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Highly Cited
2006
Highly Cited
2006
The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing.
Lin-nan Shen
,
C. Dong
,
Huanting Liu
,
J. Naismith
,
R. Hay
Biochemical Journal
2006
Corpus ID: 13142763
The SUMO (small ubiquitin-like modifier)-specific protease SENP1 (sentrin-specific protease 1) can process the three forms of…
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Highly Cited
2005
Highly Cited
2005
Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1.
Zheng Xu
,
S. Au
Biochemical Journal
2005
Corpus ID: 35293916
SUMO (small ubiquitin-related modifier) is a member of the ubiquitin-like protein family that regulates cellular function of a…
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