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Saposin C

Known as: Sphingolipid Activator Protein 2, Gaucher Activator Protein, Co-beta-Glucosidase 
National Institutes of Health

Related topics

Related topics

2 relations
PSAP gene

Broader (1)

Saposins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Cathepsin-mediated regulation of autophagy in saposin C deficiency
Saposin C deficiency, a rare variant form of Gaucher disease, is due to mutations in the prosaposin gene (PSAP) affecting saposin… 
2005
2005
Saposin C: Neuronal Effect and CNS Delivery by Liposomes
Abstract: Saposin C is one of four small lipid‐binding proteins that derive from a single precursor protein, named prosaposin… 
2004
2004
Saposin C promotes survival and prevents apoptosis via PI3K/Akt-dependent pathway in prostate cancer cells
BackgroundIn addition to androgens, growth factors are also implicated in the development and neoplastic growth of the prostate… 
Highly Cited
2003
Highly Cited
2003
Solution structure of human saposin C: pH-dependent interaction with phospholipid vesicles.
Saposin C binds to membranes to activate lipid degradation in lysosomes. To get insights into saposin C's function, we have… 
2003
2003
Phospholipid vesicle fusion induced by saposin C.
1990
1990
Activity of glucocerebrosidase in extracts of different cell types from type 1 Gaucher disease patients
Glucocerebrosidase activity in extracts of leukocytes, Epstein‐Barr virus transformed lymphocytes and fibroblasts from Portuguese… 
1990
1990
Immunocytochemical localization of sphingolipid activator protein 2 (SAP-2) in normal and SAP-deficient fibroblasts.
The intracellular localization of sphingolipid activator protein 2 (SAP-2) was determined immunocytochemically using an antiserum… 
Review
1989
Review
1989
Sphingolipid activator protein deficiency in a 16-week-old atypical Gaucher disease patient and his fetal sibling: Biochemical signs of combined sphingolipidoses
We describe a patient who presented shortly after birth with hyperkinetic behaviour, myoclonia, respiratory insufficiency and… 
Highly Cited
1981
Highly Cited
1981
Mechanism of activation of glucocerebrosidase by co-beta-glucosidase (glucosidase activator protein).
1981
1981
beta-Glucosidase activator protein from bovine spleen ("coglucosidase").
fl-Glucosidase-stimulating proteins (“co-&glucosidase”) have been isolated from bovine spleen by acidification of homogenized… 
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