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PSAP gene

Known as: SAPB, SAPC, SAP1, FORMERLY 
This gene is involved in the promotion of lipid degradation.
National Institutes of Health

Related topics

Related topics

7 relations
Lipid MetabolismLipid TransportPlatelet ActivationProactivator Polypeptide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
Targeted disruption of the mouse prosaposin gene affects the development of the prostate gland and other male reproductive organs.
The prosaposin gene encodes a 65-70 kilodalton (kd) protein, which is secreted or targeted to lysosomes. In lysosomes, prosaposin… 
Highly Cited
1999
Highly Cited
1999
Prosaposin gene expression and the efficacy of a prosaposin-derived peptide in preventing structural and functional disorders of peripheral nerve in diabetic rats.
We have recently demonstrated that prosaposin is a neurotrophic and myelinotrophic factor with the active trophic sequence… 
Highly Cited
1997
Highly Cited
1997
Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides.
Prosaposin, the precursor of saposins A, B, C, and D, was recently identified as a neurotrophic factor. Herein prosaposin was… 
Highly Cited
1995
Highly Cited
1995
A lipopolysaccharide-binding domain of the Campylobacter fetus S-layer protein resides within the conserved N terminus of a family of silent and divergent homologs
Campylobacter fetus cells can produce multiple S-layer proteins ranging from 97 to 149 kDa, with a single form predominating in… 
Highly Cited
1995
Highly Cited
1995
Structural Analysis of Saposin C and B
Saposins A, B, C, and D are a group of homologous glycoproteins derived from a single precursor, prosaposin, and apparently… 
Highly Cited
1994
Highly Cited
1994
Intermolecular association of lysosomal protein precursors during biosynthesis.
Highly Cited
1994
Highly Cited
1994
Functional human saposins expressed in Escherichia coli. Evidence for binding and activation properties of saposins C with acid beta-glucosidase.
Small (80-amino acid) glycoproteins or saposins are important for the in vivo function of several lysosomal hydrolases. Four… 
Highly Cited
1992
Highly Cited
1992
Additional biochemical findings in a patient and fetal sibling with a genetic defect in the sphingolipid activator protein (SAP) precursor, prosaposin. Evidence for a deficiency in SAP-1 and for a…
It has been shown that sphingolipid activator proteins (SAPs) 1 and 2 are encoded on the same gene along with two other putative… 
Highly Cited
1991
Highly Cited
1991
The complete sequence of a shed acute-phase antigen of Trypanosoma cruzi.
Highly Cited
1991
Highly Cited
1991
Isolation and characterization of prosaposin from human milk.
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