Proactivator Polypeptide

Known as: Prosaposin, Sphingolipid Activator Protein-1 
Proactivator polypeptide (524 aa, ~58 kDa) is encoded by the human PSAP gene. This protein is involved in sphingolipid catabolism.
National Institutes of Health

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2007
2007
CD1d molecules bind lipid antigens in the endocytic pathway, and access to the pathway is important for the development of CD1d… (More)
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Highly Cited
2004
Highly Cited
2004
It is now established that CD1 molecules present lipid antigens to T cells, although it is not clear how the exchange of lipids… (More)
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Highly Cited
2003
Highly Cited
2003
Most soluble lysosomal proteins bind the mannose 6-phosphate receptor (M6P-R) to be sorted to the lysosomes. However, the… (More)
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1999
1999
The epidermal permeability barrier is maintained by extracellular lipid membranes within the interstices of the stratum corneum… (More)
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1999
1999
Withdrawal of trophic factors necessary for Schwann cell survival regulates Schwann cell number during development and after… (More)
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1998
1998
Prosaposin, the precursor of saposins A, B, C, and D, was recently reported to be a neurotrophic factor in vivo and in vitro. The… (More)
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1997
1997
Saposins A, B, C, and D, which are required for the enzymatic hydrolysis of sphingolipids by specific lysosomal hydrolases, are… (More)
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1997
1997
Prosaposin, the precursor of saposins A, B, C, and D, was recently identified as a neurotrophic factor. Herein prosaposin was… (More)
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Highly Cited
1994
Highly Cited
1994
Prosaposin was identified as a neurotrophic factor stimulating neurite outgrowth in murine neuroblastoma (NS20Y) cells and… (More)
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1992
1992
Prosaposin, the precursor of saposins A, B, C, and D, which activate lysosomal hydrolysis of sphingolipids, exists in various… (More)
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