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SYTL1 gene

Known as: JFC1, C2 DOMAIN-CONTAINING PROTEIN JFC1, SYNAPTOTAGMIN-LIKE 1 
National Institutes of Health

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Broader (1)

Genes

Papers overview

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2019
2019
The trafficking protein JFC1 regulates Rac1‐GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration
Neutrophil chemotaxis is essential in responses to infection and underlies inflammation. In neutrophils, the small GTPase Rac1… 
Highly Cited
2012
Highly Cited
2012
Deregulation of Rab and Rab Effector Genes in Bladder Cancer
Growing evidence indicates that Rab GTPases, key regulators of intracellular transport in eukaryotic cells, play an important… 
2011
2011
Genome-Wide DNA Methylation Analysis Reveals Phytoestrogen Modification of Promoter Methylation Patterns during Embryonic Stem Cell Differentiation
Background Environmental challenges during development affect the fetal epigenome, but the period(s) vulnerable to epigenetic… 
Highly Cited
2008
Highly Cited
2008
The Rab27a Effectors JFC1/Slp1 and Munc13‐4 Regulate Exocytosis of Neutrophil Granules
Neutrophil granules contain secretory molecules that contribute to the implementation of all neutrophil functions. The molecular… 
2005
2005
The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase.
Two of the major proteins secreted by the prostate epithelium secretory cells are PSA (prostate-specific antigen) and PSAP… 
2005
2005
Akt Regulates the Subcellular Localization of the Rab27a‐Binding Protein JFC1 by Phosphorylation
Here, we show that the Rab27a‐binding protein JFC1/Slp1 (synaptotagmin‐like protein) is regulated by Akt‐mediated phosphorylation… 
2002
2002
The C2A domain of JFC1 binds to 3′-phosphorylated phosphoinositides and directs plasma membrane association in living cells
Phosphatidylinositol 3-kinase products play a central role in the regulation of several intracellular pathways via adaptor… 
2002
2002
JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells.
The human promoter region of JFC1, a phosphatidylinositol 3,4,5-trisphosphate binding ATPase, was isolated by amplification of a… 
2001
2001
JFC1, a Novel Tandem C2 Domain-containing Protein Associated with the Leukocyte NADPH Oxidase*
We have employed a yeast two-hybrid system to screen a B lymphoblast-derived cDNA library, searching for regulatory components of… 
2001
2001
Characterization of the nucleotide-binding capacity and the ATPase activity of the PIP3-binding protein JFC1
In this work, we demonstrate that the phosphatidylinositol 3,4,5-trisphosphate-binding protein JFC1 is an ATP-binding protein… 
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