• Publications
  • Influence
NADPH oxidase: an update.
TLDR
The leukocyte NADPH oxidase continues to be the object of a considerable amount of investigation by scientists who are curious as to how it works and interest in the leukocytes has increased with the growing recognition that oxidases closely related to theLeukocyte oxidase can be found in a variety of cells in which the enzymes serveA variety of purposes. Expand
Phagocytes and oxidative stress.
  • B. Babior
  • Medicine
  • The American journal of medicine
  • 28 July 2000
TLDR
A large number of highly reactive microbicidal oxidants are formed, including HOCl (hypochlorous acid), which is produced by the myeloperoxidase-catalyzed oxidation of Cl(-) by H(2)O(2); OH(*) (hydroxyl radical); ONOO(-) (peroxynitrite), formed by the reaction between O(2)(-) and NO(*); and many others. Expand
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent.
TLDR
O(2) (-) is made by leukocytes under circumstances which suggest that it may be involved in bacterial killing, and is identified as the agent responsible for the leukocyte-mediated reduction of cytochrome c. Expand
NADPH Oxidase: An Update
TLDR
T HE NADPH OXIDASES are a group of plasma membrane–associated enzymes found in a variety of cells of mesodermal origin found in professional phagocytes and B lymphocytes. Expand
The neutrophil NADPH oxidase.
TLDR
The recent identification of homologs of one of the membrane components in nonphagocytic cells will expand understanding of the biological contexts in which this system may function. Expand
Oxygen-dependent microbial killing by phagocytes (second of two parts).
  • B. Babior
  • Biology, Medicine
  • The New England journal of medicine
  • 23 March 1978
TLDR
Since Metschnikoff's discovery, hundreds of scientists studying dozens of species have reported thousands of studies on these cells, perhaps the most widely recognized of which are those of the eminent English scientists. Expand
The respiratory burst of phagocytes.
  • B. Babior
  • Chemistry, Medicine
  • The Journal of clinical investigation
  • 1 March 1984
Reperfusion injury induces apoptosis in rabbit cardiomyocytes.
TLDR
Parts of apoptosis (programmed cell death) in myocytes are identified as a response to reperfusion but not ischemia, which indicates that apoptosis may be a specific feature of reperfusions injury in cardiac myocytes, leading to late cell death. Expand
Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification.
TLDR
It is concluded that acidification is an early event in programmed cell death and may be essential for genome destruction. Expand
The respiratory burst oxidase
  • B. Babior
  • Biology, Medicine
  • Basic life sciences
  • 7 October 1994
TLDR
The respiratory burst oxidase catalyzes the production of O2− by activated phagocytes and B lymphocytes, and involves protein kinase C, MAP kinase, or both, and perhaps lipid‐mediated pathways. Expand
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