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SUPT4H1 gene

Known as: SUPT4H1, SUPT4H, SUPPRESSOR OF TY 4, S. CEREVISIAE, HOMOLOG OF, 1 
 
National Institutes of Health

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SUPT4H1 protein, human

Papers overview

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Highly Cited
2016
Highly Cited
2016
Divergence of a conserved elongation factor and transcription regulation in budding and fission yeast.
Complex regulation of gene expression in mammals has evolved from simpler eukaryotic systems, yet the mechanistic features of… Expand
Highly Cited
2011
Highly Cited
2011
Architecture of the RNA polymerase–Spt4/5 complex and basis of universal transcription processivity
Related RNA polymerases (RNAPs) carry out cellular gene transcription in all three kingdoms of life. The universal conservation… Expand
Highly Cited
2006
Highly Cited
2006
Mutations in the Saccharomyces cerevisiae RPB1 Gene Conferring Hypersensitivity to 6-Azauracil
RNA polymerase II (RNAPII) in eukaryotic cells drives transcription of most messenger RNAs. RNAPII core enzyme is composed of 12… Expand
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Highly Cited
2005
Highly Cited
2005
Npl3 is an antagonist of mRNA 3′ end formation by RNA polymerase II
Proper 3′ end formation is critical for the production of functional mRNAs. Termination by RNA polymerase II is linked to mRNA… Expand
Highly Cited
2003
Highly Cited
2003
Molecular evidence for a positive role of Spt4 in transcription elongation
We have previously shown that yeast mutants of the THO complex have a defect in gene expression, observed as an impairment of… Expand
Highly Cited
2000
Highly Cited
2000
High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongation.
Recent studies have demonstrated roles for Spt4, Spt5, and Spt6 in the regulation of transcriptional elongation in both yeast and… Expand
Highly Cited
2000
Highly Cited
2000
Spt5 and spt6 are associated with active transcription and have characteristics of general elongation factors in D. melanogaster.
The Spt4, Spt5, and Spt6 proteins are conserved throughout eukaryotes and are believed to play critical and related roles in… Expand
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Highly Cited
1998
Highly Cited
1998
DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs.
We report the identification of a transcription elongation factor from HeLa cell nuclear extracts that causes pausing of RNA… Expand
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Highly Cited
1998
Highly Cited
1998
Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae.
Previous characterization of the Saccharomyces cerevisiae Spt4, Spt5, and Spt6 proteins suggested that these proteins act as… Expand
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Highly Cited
1992
Highly Cited
1992
SPT4, SPT5 and SPT6 interactions: effects on transcription and viability in Saccharomyces cerevisiae.
The SPT4, SPT5 and SPT6 genes of Saccharomyces cerevisiae were identified originally by mutations that suppress delta insertion… Expand
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