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STAT5A gene

Known as: SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A, STAT5, MAMMARY GLAND FACTOR 
This gene plays a role in signal transduction and activation of transcription. It is involved in the immune response via stimulation of T-cell… 
National Institutes of Health

Related topics

Related topics

12 relations
17q11.2Homo sapiensSTAT5 Transcription FactorSTAT5A protein, human

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STAT5A wt Allele

Papers overview

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Highly Cited
2014
Highly Cited
2014
Targeting STAT5 in Hematologic Malignancies through Inhibition of the Bromodomain and Extra-Terminal (BET) Bromodomain Protein BRD2
The transcription factor signal STAT5 is constitutively activated in a wide range of leukemias and lymphomas, and drives the… 
Highly Cited
2005
Highly Cited
2005
Enforced expression of an Flt3 internal tandem duplication in human CD34+ cells confers properties of self-renewal and enhanced erythropoiesis.
To investigate the role of constitutively active internal tandem duplication (ITD) mutants of the Fms-like tyrosine kinase 3… 
Highly Cited
2005
Highly Cited
2005
Restricted STAT5 Activation Dictates Appropriate Thymic B versus T Cell Lineage Commitment1
The molecular mechanisms regulating lymphocyte lineage commitment remain poorly characterized. To explore the role of the IL7R in… 
Highly Cited
2003
Highly Cited
2003
Identification of Shp-2 as a Stat5A Phosphatase*
Stat5A, a member of the signal transducers and activators of transcription (Stat) family, is activated upon a single tyrosine… 
Highly Cited
2003
Highly Cited
2003
Tudor and nuclease-like domains containing protein p100 function as coactivators for signal transducer and activator of transcription 5.
Signal transducer and activator of transcription 5 (Stat5) plays a critical role in prolactin (PRL)-induced transcription of… 
Highly Cited
2003
Highly Cited
2003
Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands
Although growth factors have been shown to influence mammary gland development, the nature of downstream effectors remains… 
Highly Cited
2000
Highly Cited
2000
Cytosolic Tyrosine Dephosphorylation of STAT5
STAT5, a member of the signal transducers and activators of transcription (STATs), is important in modulating T cell functions… 
Highly Cited
1998
Highly Cited
1998
A Single Amino Acid in the DNA Binding Regions of STAT5A and STAT5B Confers Distinct DNA Binding Specificities*
STAT5A and STAT5B are two highly related transcription factors encoded by two distinct genes. STAT5A and STAT5B are activated by… 
Highly Cited
1997
Highly Cited
1997
Growth hormone-induced tyrosyl phosphorylation and deoxyribonucleic acid binding activity of Stat5A and Stat5B.
GH is known to activate JAK2 tyrosine kinase and members of the Stat family of transcription factors, including Stats 1, 3, and 5… 
Highly Cited
1997
Highly Cited
1997
Prolactin signal transduction to milk protein genes: carboxy-terminal part of the prolactin receptor and its tyrosine phosphorylation are not obligatory for JAK2 and STAT5 activation
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