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STAT5A wt Allele

Known as: MGF, STAT5, Signal Transducer and Activator of Transcription 5A wt Allele 
Human STAT5A wild-type allele is located in the vicinity of 17q11.2 and is approximately 24 kb in length. This allele, which encodes signal… 
National Institutes of Health

Related topics

Related topics

15 relations
17q11.2EGF Signaling PathwayERBB Family Signaling PathwayERBB4 Signaling Pathway

Broader (1)

STAT5A gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Activated STAT5 Confers Resistance to Intestinal Injury by Increasing Intestinal Stem Cell Proliferation and Regeneration
Highly Cited
2014
Highly Cited
2014
Stat5 Regulates the Phosphatidylinositol 3-Kinase/Akt1 Pathway during Mammary Gland Development and Tumorigenesis
ABSTRACT Stat5 (signal transducer and activator of transcription 5) is an essential mediator of cytokine receptor signaling and… 
Highly Cited
2013
Highly Cited
2013
PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis
The transcription factor STAT5 (signal transducer and activator of transcription 5) is frequently activated in hematological… 
2005
2005
Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: the key role of the STAT5 signal transduction pathway
17-allylamino-17-demethoxygeldanamycin (17-AAG), an inhibitor of the molecular chaperone heat shock protein 90, results in cell… 
1999
1999
Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation.
We have investigated mechanisms and consequences of STAT5 activation through the human IL-4 receptor (IL-4R). By functionally… 
Highly Cited
1998
Highly Cited
1998
Regulation of cell growth by IL-2: role of STAT5 in protection from apoptosis but not in cell cycle progression.
Cytokines play an essential role in the regulation of lymphocyte survival and growth. We have analyzed the pathways activated by… 
1998
1998
TNF inhibits insulin induced STAT5 activation in differentiated mouse muscle cells pmi28
1998
1998
Positive Selection of Apoptosis-resistant Cells Correlates with Activation of Dominant-Negative STAT5*
The STAT5 activation has important roles in cell differentiation, cell cycle control, and development. However, the potential… 
Highly Cited
1997
Highly Cited
1997
Growth hormone-induced tyrosyl phosphorylation and deoxyribonucleic acid binding activity of Stat5A and Stat5B.
GH is known to activate JAK2 tyrosine kinase and members of the Stat family of transcription factors, including Stats 1, 3, and 5… 
Highly Cited
1995
Highly Cited
1995
Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain.
A number of cytokines and growth factors use the JAK-STAT pathway to signal from the cell membrane to the nucleus. While… 
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