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ST2825

 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Heterocyclic Compounds, 2-RingSpiro Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
TLR4 promotes the expression of HIF-1α by triggering reactive oxygen species in cervical cancer cells in vitro-implications for therapeutic intervention
The present study investigated the mechanism underlying Toll-like receptor 4 (TLR4)-mediated stimulation of hypoxia-inducible… Expand
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2017
2017
MYD88 Inhibitor ST2825 Suppresses the Growth of Lymphoma and Leukaemia Cells.
BACKGROUND/AIM Myeloid differentiation primary response gene 88 (MYD88), which activates the nuclear factor kappa B (NF-κB… Expand
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2017
2017
Myeloid differentiation factor 88 is up-regulated in epileptic brain and contributes to experimental seizures in rats
Abstract Accumulating evidence supports that activation of inflammatory pathways is a crucial factor contributing to the… Expand
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2016
2016
Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway.
We previously reported the effects of dioscin against carbon tetrachloride-, acetaminophen- and alcohol-induced acute liver… Expand
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2016
2016
Inhibition of myeloid differentiation factor 88(MyD88) by ST2825 provides neuroprotection after experimental traumatic brain injury in mice
Myeloid differentiation factor 88(MyD88) is an endogenous adaptor protein that plays an important role in coordinating… Expand
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2016
2016
Polysaccharopeptide exerts immunoregulatory effects via MyD88-dependent signaling pathway.
AIMS The present study is to investigate the immunomodulatory mechanism and related pathways of polysaccharopeptide (PSP) in mice… Expand
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2016
2016
Effect of ST2825 on the proliferation and apoptosis of human hepatocellular carcinoma cells.
The purpose of this study was to investigate the effect of ST2825, an inhibitor of myeloid differentiation factor 88 (MyD88), on… Expand
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2015
2015
Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70.
We previously reported the effect of dioscin against hepatic ischemia/reperfusion injury (IRI) in rats. However, little is known… Expand
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2010
2010
Pharmacologic inhibition of myeloid differentiation factor 88 (MyD88) prevents left ventricular dilation and hypertrophy after experimental acute myocardial infarction in the mouse.
BACKGROUND Myeloid differentiation factor 88 (MyD88) is an endogenous adaptor protein that coordinates the inflammatory response… Expand
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Highly Cited
2007
Highly Cited
2007
Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound.
MyD88 is an adaptor protein, which plays an essential role in the intracellular signaling elicited by IL-1R and several TLRs… Expand
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