Skip to search formSkip to main contentSkip to account menu

ST14 gene

Known as: ST14, Suppression of Tumorigenicity 14 (Colon Carcinoma, Matriptase, Epithin) Gene, SUPPRESSION OF TUMORIGENICITY 14 
This gene is involved in the activation of proteases and latent growth factors in epithelial membranes.
National Institutes of Health

Related topics

Related topics

6 relations
HydrolysisPost-Translational RegulationProteolysisST18 gene

Narrower (1)

ST14 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Prostasin Is Required for Matriptase Activation in Intestinal Epithelial Cells to Regulate Closure of the Paracellular Pathway*
Background: Matriptase promotes intestinal epithelial barrier formation. Results: Matriptase and prostasin constitute a common… 
Highly Cited
2010
Highly Cited
2010
Regulation of the Matriptase-Prostasin Cell Surface Proteolytic Cascade by Hepatocyte Growth Factor Activator Inhibitor-1 during Epidermal Differentiation*
Matriptase, a membrane-tethered serine protease, plays essential roles in epidermal differentiation and barrier function, largely… 
Review
2007
Review
2007
Matriptase-dependent cell surface proteolysis in epithelial development and pathogenesis.
Matriptase is an epithelial type II transmembrane serine protease with a complex modular structure and sophisticated activation… 
Highly Cited
2007
Highly Cited
2007
Design and synthesis of novel and potent inhibitors of the type II transmembrane serine protease, matriptase, based upon the sunflower trypsin inhibitor-1.
Matriptase, initially isolated from human breast cancer cells in culture, is a member of the emerging class of type II… 
Highly Cited
2007
Highly Cited
2007
Autoactivation of matriptase in vitro: requirement for biomembrane and LDL receptor domain.
In live cells, autoactivation of matriptase, a membrane-bound serine protease, can be induced by lysophospholipids, androgens… 
Highly Cited
2005
Highly Cited
2005
In vitro inhibition of matriptase prevents invasive growth of cell lines of prostate and colon carcinoma.
Matriptase, also known as membrane-type-serine-protease 1 (MT-SP 1), is a type II transmembrane serine protease involved in the… 
Highly Cited
2005
Highly Cited
2005
Increased expression of matriptase is associated with histopathologic grades of cervical neoplasia.
Highly Cited
2002
Highly Cited
2002
Sphingosine 1-Phosphate, Present in Serum-derived Lipoproteins, Activates Matriptase*
We describe here a novel biological function of sphingosine 1-phosphate (S1P): the activation of a serine protease, matriptase… 
Highly Cited
2001
Highly Cited
2001
Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase.
Matriptase, a trypsin-like serine protease, which may be involved in tissue remodeling, cancer invasion, and metastasis. Potent… 
Highly Cited
2001
Highly Cited
2001
Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)