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ST 1481

Known as: ST1481, STI481 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (3)

7-t-butoxyiminomethylcamptothecinGimatecanLBQ707

Broader (1)

Camptothecin
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Docetaxel–ST1481 sequence exerts a potent cytotoxic activity on hormone‐resistant prostate cancer cells by reducing drug resistance‐related gene expression
The efficacy of current therapy for hormone‐refractory prostate cancer is still unsatisfactory and new agents and therapeutic… 
2009
2009
Determination of total and lactone form of a new camptothecin derivative gimatecan (ST1481) and its metabolite ST1698 in human plasma by high-performance liquid chromatography with fluorimetric…
2008
2008
Effects of drug efflux proteins and topoisomerase I mutations on the camptothecin analogue gimatecan
SummaryClinically relevant resistance to the currently approved camptothecins, irinotecan and topotecan, is poorly understood but… 
2008
2008
The topoisomerase I inhibitor gimatecan exhibits synergistic antitumor activity in combination with imatinib mesylate and everolimus against malignant glioma xenografts
2073 Background: The novel oral lipophilic camptotecan gimatecan (ST1481; NVP-LBQ707) has shown antitumor activity against… 
2006
2006
A phase II study of oral gimatecan (ST1481) in women with progressing or recurring advanced epithelial ovarian, fallopian tube and peritoneal cancers.
5088 Background: Gimatecan, a new camptothecin derivative, is a potent topoisomerase I inhibitor, active by oral route. METHODS… 
2005
2005
Cellular basis of antiproliferative and antitumor activity of the novel camptothecin derivative, gimatecan, in bladder carcinoma models.
To investigate the cellular/molecular basis of the activity of a novel lipophilic camptothecin, gimatecan (ST1481), against… 
2005
2005
The novel lipophilic camptothecin analogue gimatecan is very active in vitro in human neuroblastoma: a comparative study with SN38 and topotecan.
Highly Cited
2004
Highly Cited
2004
Subcellular localization of the camptothecin analogues, topotecan and gimatecan.
2003
2003
Cellular bases of the antitumor activity of a 7-substituted camptothecin in hormone-refractory human prostate carcinoma models.
Highly Cited
2001
Highly Cited
2001
Potent antitumor activity and improved pharmacological profile of ST1481, a novel 7-substituted camptothecin.
Relevant drawbacks of the molecular structure and mechanism of the action of camptothecins are the instability of the E ring… 
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