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Background: A prospective phase II study was conducted to evaluate the efficacy and toxicity of oral gimatecan in patients with… Expand Organic anion-transporting polypeptides (OATPs) are important uptake transporters that can have a profound impact on the systemic… Expand Topoisomerase I (TopoI), an essential enzyme, produces a DNA single strand break allowing DNA relaxation for replication. The… Expand SummaryClinically relevant resistance to the currently approved camptothecins, irinotecan and topotecan, is poorly understood but… Expand Neuroblastoma is one of the most common extracranial solid tumours in childhood with a poor prognosis in its advanced stage… Expand The anti-apoptotic protein Bcl-2 has been implicated in the intrinsic resistance of melanoma to chemotherapy. The aim of this… Expand Small‐sized liposomes have several advantages as drug delivery systems, and the ethanol injection method is a suitable technique… Expand The realization that position 7 of camptothecin allows several options in chemical manipulation of the drug has stimulated a… Expand Lipophilicity of camptothecins derivatives has been reported to improve the stability of the lactone ring and to favor rapid… Expand ST1481 (gimatecan) is a novel lipophilic camptothecin with a promising preclinical pharmacological profile. On the basis of its… Expand