Skip to search formSkip to main contentSkip to account menu

Gimatecan

An orally bioavailable, semi-synthetic lipophilic analogue of camptothecin, a quinoline alkaloid extracted from the Asian tree Camptotheca acuminate… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Esophageal squamous cell carcinoma (ESCC) is a frequently diagnosed and deadly malignancy with few standard therapeutic options… 
2010
2010
Background: A prospective phase II study was conducted to evaluate the efficacy and toxicity of oral gimatecan in patients with… 
Highly Cited
2009
Highly Cited
2009
Organic anion-transporting polypeptides (OATPs) are important uptake transporters that can have a profound impact on the systemic… 
Review
2008
2007
2007
SummaryClinically relevant resistance to the currently approved camptothecins, irinotecan and topotecan, is poorly understood but… 
2007
2007
Lipophilic camptothecin derivatives are considered to have negligible affinity for breast cancer resistance protein (BCRP; ABCG2… 
Highly Cited
2004
Highly Cited
2004
Small‐sized liposomes have several advantages as drug delivery systems, and the ethanol injection method is a suitable technique… 
Review
2004
Review
2004
The realization that position 7 of camptothecin allows several options in chemical manipulation of the drug has stimulated a… 
2003
2003
ST1481 (gimatecan) is a novel lipophilic camptothecin with a promising preclinical pharmacological profile. On the basis of its…