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Gimatecan

An orally bioavailable, semi-synthetic lipophilic analogue of camptothecin, a quinoline alkaloid extracted from the Asian tree Camptotheca acuminate… Expand
National Institutes of Health

Papers overview

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2010
2010
Background: A prospective phase II study was conducted to evaluate the efficacy and toxicity of oral gimatecan in patients with… Expand
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2009
2009
Organic anion-transporting polypeptides (OATPs) are important uptake transporters that can have a profound impact on the systemic… Expand
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Review
2008
Review
2008
  • B. Teicher
  • Biochemical pharmacology
  • 2008
  • Corpus ID: 23615580
Topoisomerase I (TopoI), an essential enzyme, produces a DNA single strand break allowing DNA relaxation for replication. The… Expand
2007
2007
SummaryClinically relevant resistance to the currently approved camptothecins, irinotecan and topotecan, is poorly understood but… Expand
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2005
2005
Neuroblastoma is one of the most common extracranial solid tumours in childhood with a poor prognosis in its advanced stage… Expand
2005
2005
The anti-apoptotic protein Bcl-2 has been implicated in the intrinsic resistance of melanoma to chemotherapy. The aim of this… Expand
Highly Cited
2004
Highly Cited
2004
Small‐sized liposomes have several advantages as drug delivery systems, and the ethanol injection method is a suitable technique… Expand
Review
2004
Review
2004
The realization that position 7 of camptothecin allows several options in chemical manipulation of the drug has stimulated a… Expand
Highly Cited
2004
Highly Cited
2004
Lipophilicity of camptothecins derivatives has been reported to improve the stability of the lactone ring and to favor rapid… Expand
2003
2003
ST1481 (gimatecan) is a novel lipophilic camptothecin with a promising preclinical pharmacological profile. On the basis of its… Expand
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