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Synovial sarcomas are aggressive spindle cell sarcomas containing in some cases areas of epithelial differentiation. They… Expand A global transcriptional co-activator, the SNF/SWI complex, has been characterized as a chromatin remodeling factor that enhances… Expand Synovial sarcomas are high‐grade malignant mesenchymal tumors with biphasic (BSS) and monophasic (MSS) variants that carry a… Expand Human synovial sarcoma has been shown to exclusively harbor the chromosomal translocation t(X;18) that produces the chimeric gene… Expand Synovial sarcoma is characterized by a specific recurrent translocation t(X; 18), resulting in either the SYT-SSX1 or SYT-SSX2… Expand Cytogenetically, synovial sarcoma (SS) is characterized by the translocation t(X;18)(p11.2;q11.2), resulting in a fusion between… Expand BACKGROUND
Synovial sarcomas account for up to 10 percent of soft-tissue sarcomas and include two major histologic subtypes… Expand SSX genes show extensive nucleotide sequence conservation but little is known of their function. Disruption of SSX1 or SSX2, by… Expand We demonstrate that the cytogenetically defined translocation t(X;18)(p11.2;q11.2) found in human synovial sarcoma results in the… Expand The translocation t(X;18)(p11;q11) is seen in > 80% of synovial sarcomas (SS) with informative karyotypes. The breakpoints of the… Expand